Sherri Alaa, Mortada Mohamad Mahdi, Makowska Joanna, Sokolowska Milena, Lewandowska-Polak Anna
Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
Department of Immune Metabolism, Swiss Institute of Asthma and Allergy Research (SIAF), Davos, Switzerland.
Rheumatol Int. 2024 Dec;44(12):2699-2709. doi: 10.1007/s00296-024-05729-8. Epub 2024 Oct 23.
The interplay between Psoriatic arthritis and Gout is a current diagnostic challenge faced by many physicians and researchers. We aimed at reviewing the coexistence of gout and its features such as hyperuricemia and deposition of monosodium urate crystals in patients with psoriatic arthritis (PsA). We also focused on a brief presentation of the pathophysiology underneath the interplay between PsA and gout, and ultimately on recommendation of approaches for the differential diagnosis. The literature search for this narrative review was conducted using PubMed and Medline and after retrieving and screening the references, articles were selected according to the inclusion and exclusion criteria. Part of the assessed studies reported the coexistence of PsA and gout (Psout) and its association with several clinical outcomes among affected patients. Other studies stressed incidences of misdiagnosis of gout with PsA and vice versa. Additionally, the presence of hyperuricemia in PsA patients could interfere with the patient's characteristics and outcomes of their treatment. Further research on the assessment and clinical course of Psout is required to develop an official protocol for its diagnosis and treatment.
银屑病关节炎与痛风之间的相互作用是目前许多医生和研究人员面临的诊断挑战。我们旨在回顾痛风在银屑病关节炎（PsA）患者中的共存情况及其特征，如高尿酸血症和尿酸钠晶体沉积。我们还重点简要介绍了PsA与痛风相互作用背后的病理生理学，并最终给出鉴别诊断方法的建议。本次叙述性综述的文献检索使用了PubMed和Medline，在检索和筛选参考文献后，根据纳入和排除标准选择文章。部分评估研究报告了PsA与痛风（Psout）的共存情况及其与受影响患者的几种临床结局的关联。其他研究强调了痛风与PsA误诊的发生率，反之亦然。此外，PsA患者中高尿酸血症的存在可能会干扰患者的特征及其治疗结局。需要对Psout的评估和临床过程进行进一步研究，以制定其诊断和治疗的官方方案。
