去整合素和金属蛋白酶9（ADAM9）的过表达与口腔鳞状细胞癌患者的不良预后相关。
Overexpression of a disintegrin and metalloproteinase 9 (ADAM9) in relation to poor prognosis of patients with oral squamous cell carcinoma.
作者信息
Wu Shuangjiang, Cheng Lang, Luo Tao, Makeudom Anupong, Wang Lei, Krisanaprakornkit Suttichai
机构信息
Department of Oral and Maxillofacial Surgery, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, China.
出版信息
Discov Oncol. 2024 Oct 23;15(1):582. doi: 10.1007/s12672-024-01422-1.
This study investigates the expressions of ADAM9, CDCP1 and t-PA in OSCC and their impacts on patient prognosis. Previous research has demonstrated the overexpression of ADAM9 and activation of plasminogen activator in OSCC, but CDCP1's role remains unexplored. While these biomolecules are known to contribute to lung cancer metastasis, their concurrent expressions in OSCC have not been thoroughly examined. Our aim is to assess the expressions of ADAM9, CDCP1, and t-PA in OSCC specimens, compare them with normal oral tissues, and explore their correlation with OSCC's clinicopathological features and patient survival outcomes.
本研究调查了ADAM9、CDCP1和t-PA在口腔鳞状细胞癌（OSCC）中的表达及其对患者预后的影响。先前的研究已证明ADAM9在OSCC中过表达以及纤溶酶原激活剂的激活，但CDCP1的作用仍未得到探索。虽然已知这些生物分子有助于肺癌转移，但它们在OSCC中的同时表达尚未得到充分研究。我们的目的是评估ADAM9、CDCP1和t-PA在OSCC标本中的表达，将它们与正常口腔组织进行比较，并探讨它们与OSCC临床病理特征和患者生存结果的相关性。
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