Department of Rheumatology and Immunology, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing, 400010, China.
Clin Rheumatol. 2024 Dec;43(12):3821-3827. doi: 10.1007/s10067-024-07146-5. Epub 2024 Oct 23.
To evaluate the frequency and the clinical relevance of thyroid disease in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients.
A total of 305 AAV patients admitted to the Second Affiliated Hospital of Chongqing Medical University between October 2010 and December 2023 were analyzed. Demographic, clinical, and laboratory data were compared between AAV patients with and without thyroid disease. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with thyroid disease in AAV patients.
Among the 305 AAV patients, 52 (17.0%) had concurrent thyroid disease. In univariate analysis, gender, coronary artery disease, renal involvement, anti-Ro/SSA antibodies, anti-Ro52 antibodies, anti-thyroglobulin antibodies (TgAb), and anti-thyroid peroxidase antibodies (TPOAb) exhibited significant differences between AAV patients with and without thyroid disease (P < 0.05). Multivariate analysis revealed that female gender (odds ratio (OR) = 2.423, 95% confidence interval (95% CI) 1.241, 4.729; P = 0.009), concurrent coronary artery disease (OR = 2.998, 95% CI 1.280, 7.019; P = 0.011), and positive anti-Ro/SSA antibodies (OR = 4.697, 95% CI 1.960, 11.257; P = 0.001) were associated with thyroid disease in AAV patients.
AAV patients have a higher incidence of thyroid disease. Regular monitoring of thyroid function is advised for AAV patients, particularly for women, those with coronary artery disease, and those who are positive for anti-Ro/SSA antibodies. Key Points • AAV patients have a higher incidence of thyroid disease. • The potential clinical relevance of AAV patients with thyroid disease was explored. • Regular monitoring of thyroid function is advised for AAV patients.
评估抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）患者甲状腺疾病的发生频率及其临床相关性。
对 2010 年 10 月至 2023 年 12 月期间在重庆医科大学第二附属医院住院的 305 例 AAV 患者进行分析。比较 AAV 患者中有无甲状腺疾病的患者的人口统计学、临床和实验室数据。采用单因素和多因素逻辑回归分析确定与 AAV 患者甲状腺疾病相关的因素。
在 305 例 AAV 患者中，有 52 例（17.0%）同时患有甲状腺疾病。在单因素分析中，性别、冠状动脉疾病、肾脏受累、抗 Ro/SSA 抗体、抗 Ro52 抗体、抗甲状腺球蛋白抗体（TgAb）和抗甲状腺过氧化物酶抗体（TPOAb）在 AAV 患者中有和无甲状腺疾病患者之间存在显著差异（P<0.05）。多因素分析显示，女性（比值比（OR）=2.423，95%置信区间（95%CI）1.241，4.729；P=0.009）、合并冠状动脉疾病（OR=2.998，95%CI 1.280，7.019；P=0.011）和抗 Ro/SSA 抗体阳性（OR=4.697，95%CI 1.960，11.257；P=0.001）与 AAV 患者的甲状腺疾病相关。
AAV 患者甲状腺疾病的发病率较高。建议对 AAV 患者，特别是女性、合并冠状动脉疾病和抗 Ro/SSA 抗体阳性的患者，定期监测甲状腺功能。
AAV 患者甲状腺疾病的发病率较高。
探讨了 AAV 患者甲状腺疾病的潜在临床相关性。
建议对 AAV 患者定期监测甲状腺功能。
