From the Imperial College London, London, UK.
M. Prendecki, MBBS, Imperial College London; L. Martin, MD, Imperial College London; A. Tanna, MBBS, Imperial College London; M. Antonelou, MBBS, Imperial College London; and C.D. Pusey, DSc, Imperial College London.
J Rheumatol. 2018 May;45(5):686-689. doi: 10.3899/jrheum.170661. Epub 2018 Mar 15.
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been linked with thyroid disease as a result of antithyroid medications. We assessed the prevalence of thyroid disease in our patients with AAV.
Clinical records of 279 patients with AAV diagnosed between 1991 and 2014 were analyzed.
Thyroid disease was identified in 21.5% of patients, but only 2 had previously received propylthiouracil. There was a greater proportion of female patients, patients with antimyeloperoxidase antibodies, and patients with renal disease in the group with thyroid disease.
Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs.
由于抗甲状腺药物的作用，抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）与甲状腺疾病有关。我们评估了我们的 AAV 患者中甲状腺疾病的患病率。
分析了 1991 年至 2014 年间诊断的 279 例 AAV 患者的临床记录。
21.5%的患者存在甲状腺疾病，但只有 2 例曾接受丙硫氧嘧啶治疗。在甲状腺疾病组中，女性患者、抗髓过氧化物酶抗体患者和肾脏疾病患者的比例更高。
我们的数据显示，AAV 患者的甲状腺疾病患病率高于普通人群，但这并不是由于抗甲状腺药物所致。
