Department of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Japan.
Cancer Rep (Hoboken). 2024 Oct;7(10):e70014. doi: 10.1002/cnr2.70014.
Angiosarcoma, a very rare malignant tumor constituting 2%-4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcinoma. The difficulty arises from the shared epithelial-like morphology and expression of epithelial markers in immunohistochemistry.
This study reports a case where EAS diagnosis was achieved through a combination of gross findings in a lung resection sample, imprint cytology, and immunocytochemistry. Imprint cytology revealed clusters of epithelioid cells, while immunocytochemistry showed positive results for CD31, ERG, Fli-1, and AE1/AE3, proving instrumental in diagnosing EAS. The described immunocytochemical protocol facilitates prompt diagnosis exclusively through cytology samples.
This report emphasizes the potential for diagnosing EAS using cytological specimens, which is especially useful in cases where obtaining tissue samples proves challenging.
血管肉瘤是一种非常罕见的恶性肿瘤，占软组织肉瘤的 2%-4%，可发生于包括皮肤、软组织和骨骼在内的多种器官。组织学上，血管肉瘤具有广泛的形态学特征，上皮样血管肉瘤（EAS）类似于癌。其诊断难点在于免疫组化中上皮样形态和上皮标志物的表达具有相似性。
本研究报告了一例通过肺切除标本的大体观察、印片细胞学和免疫细胞化学相结合而诊断为 EAS 的病例。印片细胞学显示出上皮样细胞簇，免疫细胞化学显示 CD31、ERG、Fli-1 和 AE1/AE3 阳性，有助于诊断 EAS。所描述的免疫细胞化学方案通过细胞学样本即可实现快速诊断。
本报告强调了使用细胞学标本诊断 EAS 的可能性，这在获取组织标本困难的情况下尤为有用。
