Krabbe S, Hummer L, Christiansen C
J Clin Endocrinol Metab. 1986 Mar;62(3):503-7. doi: 10.1210/jcem-62-3-503.
We determined the serum concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D [1,25-(OH)2D], 24,25-(OH)2D, and 25,26-(OH)2D every third month in a 2-yr longitudinal study of 20 normal pubertal boys. Seasonal fluctuations and highly significant correlations with the hours of sunshine were found for 25-hydroxyvitamin D, 24,25-(OH)2D and 25,26-(OH)2D, whereas the serum concentrations of 1,25-(OH)2D were not related to sunshine duration. The boys were grouped according to the time at which the maximal increase in serum testosterone occurred, and the serum vitamin D metabolite levels were examined in relation to this point. No significant changes in the serum levels of the vitamin D metabolites were found. When compiling the data according to clinical evaluation of puberty estimated by pubic hair stages (PH1 to PH4), no significant changes in the serum levels of vitamin D metabolites were found. The present data indicate that the marked increase in serum testosterone in male puberty has no significant influence on circulating vitamin D metabolite levels.
在一项针对20名正常青春期男孩的为期两年的纵向研究中，我们每三个月测定一次血清中25-羟基维生素D、1,25-二羟基维生素D [1,25-(OH)2D]、24,25-(OH)2D和25,26-(OH)2D的浓度。发现25-羟基维生素D、24,25-(OH)2D和25,26-(OH)2D存在季节性波动，且与日照时长高度显著相关，而1,25-(OH)2D的血清浓度与日照时长无关。根据血清睾酮最大增幅出现的时间对男孩进行分组，并据此检查血清维生素D代谢物水平。未发现维生素D代谢物的血清水平有显著变化。根据阴毛分期（PH1至PH4）对青春期进行临床评估来汇总数据时，也未发现维生素D代谢物的血清水平有显著变化。目前的数据表明，男性青春期血清睾酮的显著增加对循环维生素D代谢物水平没有显著影响。
