Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Pushpagiri Institute of Medical Sciences and Research Centre, Mendicity, Perumthuruthy, Tiruvalla, Kerala, India.
Department of Oral and Maxillofacial Diseases, Helsinki University and University Hospital, Helsinki, Finland; Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Bioorg Med Chem. 2024 Nov 15;114:117962. doi: 10.1016/j.bmc.2024.117962. Epub 2024 Oct 19.
Photodynamic Therapy (PDT) is a rapidly evolving, non-invasive treatment modality with considerable promise in dental pharmacotherapeutics. This review article comprehensively examines PDT, beginning with its principles and then delving into its diverse applications in dentistry, including periodontal disease, endodontics, oral cancer, dental implants, and dental caries. Each area presents the latest research and discusses the potential benefits and challenges. The unique advantages of PDT are highlighted, such as selective targeting, broad-spectrum antimicrobial effect, lack of resistance development, and its synergistic effect with other treatments. However, challenges such as photosensitizer delivery, light penetration, oxygen availability, and the need to standardize protocols are also acknowledged. The review further explores future perspectives of PDT in dentistry, including advancements in photosensitizer design, overcoming hypoxic limitations, personalized protocols, integration with other therapies, and standardization and regulation. The potential of advanced technologies, such as nanotechnology and synthetic biology, to improve PDT outcomes is also discussed. The review concludes that while PDT has shown immense potential to revolutionize dental pharmacotherapeutics, further high-quality research is needed to translate this potential into everyday dental practice. The promising future of PDT in dentistry suggests a more effective and less invasive treatment option for a range of dental conditions.
光动力疗法（PDT）是一种快速发展的非侵入性治疗方式，在牙科药物治疗中有很大的应用潜力。本文全面综述了 PDT，首先介绍其原理，然后深入探讨其在牙科领域的多种应用，包括牙周病、牙髓病、口腔癌、牙科植入物和龋齿。每个领域都呈现了最新的研究，并讨论了潜在的益处和挑战。还强调了 PDT 的独特优势，如选择性靶向、广谱抗菌作用、不易产生耐药性以及与其他治疗方法的协同作用。然而，也承认了一些挑战，如光敏剂输送、光穿透、氧气供应以及需要标准化方案等问题。本文还进一步探讨了 PDT 在牙科领域的未来展望，包括光敏剂设计的进步、克服缺氧限制、个性化方案、与其他疗法的整合以及标准化和监管。还讨论了先进技术（如纳米技术和合成生物学）在改善 PDT 效果方面的潜力。本文的结论是，虽然 PDT 已显示出极大的潜力来彻底改变牙科药物治疗，但需要进一步进行高质量的研究，将这种潜力转化为日常的牙科实践。PDT 在牙科领域的前景光明，为一系列牙科疾病提供了更有效、侵入性更小的治疗选择。
