Choi Joon Hyuk, Thung Swan N
Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Yeungnam Med Sci. 2025;42:5. doi: 10.12701/jyms.2024.00766. Epub 2024 Oct 24.
Well-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. These lesions often include focal nodular hyperplasia, hepatocellular adenoma, macroregenerative nodule, dysplastic nodule, and well-differentiated hepatocellular carcinoma. The diagnosis of these lesions remains challenging because of their morphological similarities, particularly when examined using needle biopsy. The accurate diagnosis of WDHLs is crucial for patient management and prognosis. This review addresses the histopathological characteristics and diagnostic approaches of WDHLs.
高分化肝细胞性病变（WDHLs）是指细胞与正常肝细胞极为相似的肝脏肿瘤或非肿瘤性病变。这些病变通常包括局灶性结节性增生、肝细胞腺瘤、大再生结节、发育异常结节以及高分化肝细胞癌。由于这些病变在形态上相似，尤其是在针吸活检检查时，其诊断仍然具有挑战性。准确诊断WDHLs对于患者的管理和预后至关重要。本综述阐述了WDHLs的组织病理学特征和诊断方法。
