Liu Yandong, Deng Qiang, Zhang Yanjun, Li Zhongfeng, Peng Randong, Chen Bo
Graduate School, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.
Spinal Disease Diagnosis and Treatment Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China. *Corresponding author, E-mail:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024 Oct;40(10):948-953.
Sarcopenia and osteoporosis do not develop independently. Rather, there is a close physiological and pathological relationship between them, often leading to the condition known as osteo-sarcopenia. This relationship also provides a basis for exploring the common mechanisms of muscle regeneration and bone remodeling. In the process of muscle and bone degeneration, inflammation is an important mechanism for disease progression, and the balance between regulatory T cells (Tregs) and Th17 cells is an important regulatory mechanism for immune equilibrium and inflammatory response. If the number and function of Tregs are impaired, coupled with an increase in the activity of Th17 cells, an imbalance between Tregs and Th17 cells occurs, leading to an increase in inflammatory response and an accumulation of tissue damage, and ultimately impairing myogenic and osteogenic functions. By regulating the Treg/Th17 cell immune balance, symptoms of muscle and bone degeneration can be improved.
肌肉减少症和骨质疏松症并非独立发生。相反，它们之间存在密切的生理和病理关系，常导致骨肌减少症这种情况。这种关系也为探索肌肉再生和骨重塑的共同机制提供了基础。在肌肉和骨骼退变过程中，炎症是疾病进展的重要机制，调节性T细胞（Tregs）和Th17细胞之间的平衡是免疫平衡和炎症反应的重要调节机制。如果Tregs的数量和功能受损，再加上Th17细胞活性增加，就会出现Tregs和Th17细胞之间的失衡，导致炎症反应增加和组织损伤积累，最终损害成肌和成骨功能。通过调节Treg/Th17细胞免疫平衡，可以改善肌肉和骨骼退变的症状。
