Kunming Medical University School of Stomatology and Affiliated Stomatology Hospital, Kunming, Yunnan Province, China.
Immun Inflamm Dis. 2024 Sep;12(9):e70011. doi: 10.1002/iid3.70011.
Bone regeneration is a well-regulated dynamic process, of which the prominent role of the immune system on bone homeostasis is more and more revealed by recent research. Before fully activation of the bone remodeling cells, the immune system needs to clean up the microenvironment in facilitating the bone repair initiation. Furthermore, this microenvironment must be maintained properly by various mechanisms over the entire bone regeneration process.
This review aims to summarize the role of the T-helper 17/Regulatory T cell (Th17/Treg) balance in bone cell remodeling and discuss the relevant progress in bone tissue engineering.
The role of the immune response in the early stages of bone regeneration is crucial, especially the impact of the Th17/Treg balance on osteoclasts, mesenchymal stem cells (MSCs), and osteoblasts activity. By virtue of these knowledge advancements, innovative approaches in bone tissue engineering, such as nano-structures, hydrogel, and exosomes, are designed to influence the Th17/Treg balance and thereby augment bone repair and regeneration.
Targeting the Th17/Treg balance is a promising innovative strategy for developing new treatments to enhance bone regeneration, thus offering potential breakthroughs in bone injury clinics.
骨再生是一个受到良好调控的动态过程，最近的研究越来越揭示了免疫系统在骨稳态中的突出作用。在骨重塑细胞被充分激活之前，免疫系统需要清理微环境，以促进骨修复的启动。此外，在整个骨再生过程中，各种机制必须正确维持这个微环境。
本综述旨在总结辅助性 T 细胞 17/调节性 T 细胞（Th17/Treg）平衡在骨细胞重塑中的作用，并讨论骨组织工程学中的相关进展。
免疫反应在骨再生的早期阶段起着至关重要的作用，特别是 Th17/Treg 平衡对破骨细胞、间充质干细胞（MSCs）和成骨细胞活性的影响。基于这些知识的进展，在骨组织工程学中设计了创新方法，如纳米结构、水凝胶和外泌体，以影响 Th17/Treg 平衡，从而增强骨修复和再生。
针对 Th17/Treg 平衡是开发新的治疗方法以增强骨再生的有前途的创新策略，从而为骨损伤临床提供潜在的突破。
