Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 5042 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 5042 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA; Center for Translational Lung Biology, 5042 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Clin Chest Med. 2024 Dec;45(4):797-807. doi: 10.1016/j.ccm.2024.08.002. Epub 2024 Sep 20.
Several environmental exposures increase susceptibility to the acute respiratory distress syndrome (ARDS). Specifically, chronic exposure to ambient air pollution, cigarette smoke, and alcohol "prime" the lung via epithelial injury, endothelial dysfunction, and immunomodulatory mechanisms, increasing the risk and severity of ARDS following an array of acute insults. Future research of these pathways may reveal therapeutic targets. Relevant emerging threats, such as electronic cigarettes and vaping, wildfire smoke, and the environmental hazards associated with climate change, may also be associated with ARDS. Building upon existing public policy interventions can prevent substantial morbidity and mortality from ARDS.
几种环境暴露会增加急性呼吸窘迫综合征（ARDS）的易感性。具体而言，慢性暴露于环境空气污染、香烟烟雾和酒精会通过上皮损伤、内皮功能障碍和免疫调节机制“启动”肺部，增加在受到多种急性损伤后发生 ARDS 的风险和严重程度。对这些途径的未来研究可能会揭示治疗靶点。相关的新兴威胁，如电子烟和蒸气、野火烟雾以及与气候变化相关的环境危害，也可能与 ARDS 有关。在现有公共政策干预措施的基础上，可以预防 ARDS 导致的大量发病率和死亡率。
