Graduate School of Biomedical and Health Sciences, Hiroshima University.
School of Pharmaceutical Sciences, Hiroshima University.
Chem Pharm Bull (Tokyo). 2024;72(10):909-912. doi: 10.1248/cpb.c24-00433.
We have developed a method for the site-selective hydrogenation of unactivated alkenes using 8-aminoquinoline amide as the directing group. For unactivated alkenes with two C-C double bonds, Daugulis's 8-aminoquinoline amide facilitated the site-selective hydrogenation of the desired C-C double bond, producing a product in which one C-C double bond was reduced. Site-selective reduction methodologies using intramolecular directing groups are expected to contribute significantly to the synthesis of molecules with multiple reducible functional groups in the future.
我们开发了一种使用 8-氨基喹啉酰胺作为导向基团的区域选择性加氢方法，用于未活化的烯烃。对于具有两个 C-C 双键的未活化烯烃，Daugulis 的 8-氨基喹啉酰胺促进了所需 C-C 双键的区域选择性加氢，生成了一个 C-C 双键被还原的产物。使用分子内导向基团的区域选择性还原方法有望在未来为合成具有多个可还原官能团的分子做出重大贡献。
