掌控中的细胞黏附分子：衰老的脑巨噬细胞微调中风免疫反应
CAMs in command: aging brain macrophages fine-tune stroke immune responses.
作者信息
Ritzel Rodney M, Jiang Danye, McCullough Louise D
机构信息
Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
出版信息
Trends Neurosci. 2024 Dec;47(12):965-967. doi: 10.1016/j.tins.2024.10.002. Epub 2024 Oct 22.
Abstract
Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.
摘要
中枢神经系统相关巨噬细胞（CAMs）是位于血液与脑实质之间界面处的一类独特免疫细胞亚群。在最近一项针对小鼠的研究中，勒瓦尔德及其同事发现，CAMs仅在老年动物中风后调节免疫细胞运输、内皮细胞活化和抗原呈递，这突出了使用与转化相关的模型来研究年龄相关疾病的重要性。
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本文引用的文献
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2
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Trends Immunol. 2024 May;45(5):346-357. doi: 10.1016/j.it.2024.03.007. Epub 2024 Apr 16.
3
The stunning clodronate.令人惊叹的氯膦酸盐。
J Exp Med. 2023 Jun 5;220(6). doi: 10.1084/jem.20230339. Epub 2023 Mar 28.
4
Sex differences in the inflammatory response to stroke.性别差异与卒中后的炎症反应。
Semin Immunopathol. 2023 May;45(3):295-313. doi: 10.1007/s00281-022-00969-x. Epub 2022 Nov 10.
5
Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.小胶质细胞和与中枢神经系统相关的巨噬细胞——从起源到疾病调节。
Annu Rev Immunol. 2021 Apr 26;39:251-277. doi: 10.1146/annurev-immunol-093019-110159. Epub 2021 Feb 8.
6
Alcohol exposure-induced neurovascular inflammatory priming impacts ischemic stroke and is linked with brain perivascular macrophages.酒精暴露诱导的神经血管炎症启动会影响缺血性中风，并与脑周细胞巨噬细胞有关。
JCI Insight. 2020 Feb 27;5(4):129226. doi: 10.1172/jci.insight.129226.
7
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