令人惊叹的氯膦酸盐。
The stunning clodronate.
机构信息
Developmental Biology of the Immune System, Life & Medical Sciences Institute, University of Bonn , Bonn, Germany.
出版信息
J Exp Med. 2023 Jun 5;220(6). doi: 10.1084/jem.20230339. Epub 2023 Mar 28.
Abstract
Not only macrophages, but also neutrophils, are a main target of clodronate. In this issue of JEM, Culemann et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20220525) demonstrate that anti-inflammatory effects of clodronate liposomes are driven via stunning of polymorphonuclear neutrophils and not solely through depletion of macrophages.
摘要
不仅巨噬细胞，中性粒细胞也是氯膦酸酯的主要靶标。在本期的《实验医学杂志》中，Culemann 等人（2023. J. Exp. Med.https://doi.org/10.1084/jem.20220525）表明，氯膦酸酯脂质体的抗炎作用是通过中性粒细胞的失活而不是仅仅通过巨噬细胞耗竭来驱动的。
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