Wnt细胞表面信号体及其生物发生的线索。
Clues into Wnt cell surface signalosomes and its biogenesis.
作者信息
Schmiege Philip, Li Xiaochun
机构信息
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Trends Biochem Sci. 2024 Dec;49(12):1042-1045. doi: 10.1016/j.tibs.2024.09.007. Epub 2024 Oct 22.
Abstract
Wnt morphogens induce signaling via binding their extracellular receptors. Here, we discuss several recent structural studies showing how Wnts engage their receptors frizzled (FZD) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6), how Cachd1 has been shown as an alternative initiator of Wnt signaling, and how lipidated Wnt may be produced and secreted from the cell.
摘要
Wnt形态发生素通过与其细胞外受体结合来诱导信号传导。在此，我们讨论了几项最近的结构研究，这些研究展示了Wnt如何与它们的受体卷曲蛋白（FZD）和低密度脂蛋白受体相关蛋白5/6（LRP5/6）结合，Cachd1如何被证明是Wnt信号传导的另一种启动因子，以及脂化的Wnt如何在细胞中产生和分泌。
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