Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
Nat Genet. 2010 Jun;42(6):492-4. doi: 10.1038/ng.585. Epub 2010 May 9.
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.
利用来自一项针对 907 名儿童急性淋巴细胞白血病（病例）患者和 2398 名对照者的全基因组关联研究的数据，以及在总计 2386 名病例和 2419 名对照者样本中的验证，我们已经证明，9p21.3 上的常见变异（rs3731217，CDKN2A 内含子 1）会影响急性淋巴细胞白血病的风险（比值比=0.71，P=3.01 x 10(-11)），而与细胞谱系无关。
