Department of Biotechnology, Cochin University of Science and Technology, Kerala, 682022, India.
Department of Polymer Science and Rubber Technology, Cochin University of Science and Technology, Kerala, 682022, India.
Arch Microbiol. 2024 Oct 23;206(11):443. doi: 10.1007/s00203-024-04168-0.
The growing threat of antimicrobial resistance has made the quest for antibiotic alternatives or synergists one of the most pressing priorities of the 21st century. The emergence of multidrug-resistance in most of the common wound pathogens has amplified the risk of antibiotic-resistant wound infections. Bacteriophages, with their self-replicating ability and targeted specificity, can act as suitable antibiotic alternatives. Nevertheless, targeted delivery of phages to infection sites remains a crucial issue, specifically in the case of topical infections. Hence, different phage delivery systems have been studied in recent years. However, there have been no recent reviews of phage delivery systems focusing exclusively on phage application on wounds. This review provides a compendium of all the major delivery systems that have been used to deliver phages to wound infection sites. Special focus has also been awarded to phage-embedded hydrogels with a discussion on the different aspects to be considered during their preparation.
抗生素耐药性的威胁日益增加，使得寻找抗生素替代品或协同剂成为 21 世纪最紧迫的任务之一。大多数常见伤口病原体的多药耐药性的出现增加了抗生素耐药性伤口感染的风险。噬菌体具有自我复制能力和靶向特异性，可以作为合适的抗生素替代品。然而，噬菌体靶向递送到感染部位仍然是一个关键问题，特别是在局部感染的情况下。因此，近年来已经研究了不同的噬菌体递送系统。然而，目前还没有专门针对噬菌体在伤口应用的噬菌体递送系统的最新综述。本综述提供了所有主要递送系统的纲要，这些系统已被用于将噬菌体递送到伤口感染部位。特别关注的是噬菌体嵌入水凝胶，并讨论了在制备过程中需要考虑的不同方面。
