噬菌体在治疗伤口感染中的局部应用。
Topical application of bacteriophages for treatment of wound infections.
机构信息
Advanced Drug Delivery Group, The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, New South Wales, Australia.
Phage Consulting, Sydney, New South Wales, Australia.
出版信息
Transl Res. 2020 Jun;220:153-166. doi: 10.1016/j.trsl.2020.03.010. Epub 2020 Mar 19.
Abstract
Wound infections associated with multidrug-resistant (MDR) bacteria are one of the important threats to public health. Bacteriophage (phage) therapy is a promising alternative or supplementary therapeutic approach to conventional antibiotics for combating MDR bacterial infections. In recent years, significant effort has been put into the development of phage formulations and delivery methods for topical applications, along with preclinical and clinical uses of phages for the treatment of acute and chronic wound infections. This paper reviews the application of phages for wound infections, with focus on the current status of phage formulations (including liquid, semi-solid and liposome-encapsulated formulations, phage-immobilized wound dressings), safety and efficacy assessment in clinical settings and major challenges to overcome.
摘要
与耐多药（MDR）细菌相关的伤口感染是对公共健康的重要威胁之一。噬菌体（phage）治疗是一种有前途的替代或补充治疗方法，可用于对抗耐多药细菌感染，替代传统抗生素。近年来，人们投入了大量精力开发用于局部应用的噬菌体配方和递送方法，以及噬菌体在治疗急性和慢性伤口感染方面的临床前和临床应用。本文综述了噬菌体在伤口感染中的应用，重点介绍了噬菌体配方的现状（包括液体、半固体和脂质体包封配方、噬菌体固定的伤口敷料）、临床环境中的安全性和疗效评估以及需要克服的主要挑战。
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