Depletion of ATP13A2 in adult brain induces a Parkinsonian phenotype in mice and non-human primates.
作者信息
Baekelandt Veerle
机构信息
Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
出版信息
NPJ Parkinsons Dis. 2024 Oct 23;10(1):193. doi: 10.1038/s41531-024-00814-y.
Abstract
摘要
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本文引用的文献
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Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in a pilot study in non-human primates.在一项针对非人类灵长类动物的初步研究中，黑质ATP13A2缺失会引发帕金森病相关的神经退行性变。
NPJ Parkinsons Dis. 2024 Aug 1;10(1):141. doi: 10.1038/s41531-024-00757-4.
2
Adult-onset deletion of ATP13A2 in mice induces progressive nigrostriatal pathway dopaminergic degeneration and lysosomal abnormalities.成年小鼠中ATP13A2的缺失会导致进行性黑质纹状体通路多巴胺能神经元变性和溶酶体异常。
NPJ Parkinsons Dis. 2024 Jul 20;10(1):133. doi: 10.1038/s41531-024-00748-5.
3
Rodent models based on endolysosomal genes involved in Parkinson's disease.基于帕金森病相关内溶酶体基因的啮齿动物模型。
Curr Opin Neurobiol. 2022 Feb;72:55-62. doi: 10.1016/j.conb.2021.09.004. Epub 2021 Oct 7.
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