Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
The Second Clinical Medical School, Nanchang University, Nanchang, China.
BMC Public Health. 2024 Oct 23;24(1):2942. doi: 10.1186/s12889-024-20443-7.
To examine the correlation between healthy lifestyle patterns, their change trajectories, and the risk of multimorbidity in adults.
Based on two representative national cohorts, the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) including adults aged 50 years and over. We employed Cox regression, lifestyle change trajectories, and restricted mean survival times to explore the relationship between lifestyle (assessed by SCORE2, LE'8, and HLS scores) and multimorbidity. We also conducted mediation analysis to investigate the underlying mechanisms.
A healthy lifestyle (higher LE'8, higher HLS, or lower SCORE2) can reduce the risk of multimorbidity. 2-10% lower multimorbidity risk per one-point increase in LE'8 and HLS. The hazard ratio of multimorbidity for improvements in unhealthy lifestyles or deterioration in healthy lifestyles compared to always healthy lifestyles ranged from 1.598 to 5.602. Besides, for LE'8 and HLS, participants with higher scores had a slower decrease in survival probability in ELSA. Triglyceride, C-reaction protein, fibrinogen, and cystatin C partly mediate the association between lifestyle and multimorbidity.
Keeping a healthy lifestyle over time can help reduce the risk of multimorbidity.
探讨健康生活方式模式及其变化轨迹与成年人多病共存风险之间的相关性。
基于两项具有代表性的全国性队列研究，即英国老龄化纵向研究（ELSA）和健康与退休研究（HRS），纳入年龄在 50 岁及以上的成年人。我们采用 Cox 回归、生活方式变化轨迹和限制平均生存时间来探讨生活方式（通过 SCORE2、LE'8 和 HLS 评分评估）与多病共存之间的关系。我们还进行了中介分析，以探讨潜在的机制。
健康的生活方式（更高的 LE'8、更高的 HLS 或更低的 SCORE2）可以降低多病共存的风险。LE'8 和 HLS 每增加一分，多病共存的风险降低 2-10%。与一直保持健康生活方式相比，不健康生活方式的改善或健康生活方式的恶化与多病共存的风险比范围从 1.598 到 5.602。此外，对于 LE'8 和 HLS，得分较高的参与者在 ELSA 中的生存概率下降速度较慢。甘油三酯、C 反应蛋白、纤维蛋白原和胱抑素 C 部分介导了生活方式与多病共存之间的关联。
随着时间的推移保持健康的生活方式有助于降低多病共存的风险。
