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早用曲安奈德玻璃体内注射治疗葡萄膜炎性黄斑水肿:医生调查。

Early adoption of triamcinolone acetonide suprachoroidal injection for uveitic macular edema: a physician survey.

机构信息

Retina Consultants of Texas, Houston, TX, USA.

Retina Consultants, Hartford, CT, USA.

出版信息

BMC Res Notes. 2024 Oct 23;17(1):317. doi: 10.1186/s13104-024-06969-4.

DOI:10.1186/s13104-024-06969-4
PMID:39444009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11515593/
Abstract

OBJECTIVE

To obtain physicians' "real-world" perspectives on early experiences with triamcinolone acetonide suprachoroidal injection (SCS-TA) for treatment of patients with uveitic macular edema (UME).

RESULTS

Twelve retina/uveitis specialists in the United States were surveyed about SCS-TA injection procedure and patient outcomes. Survey participants administered ≥ 291 SCS-TA injections to 243 patients with UME with various disease characteristics (etiologies, chronicity, and anatomical subtypes). Commonly reported reasons for SCS-TA adoption included potential for lowering the risk of steroid-associated intraocular pressure elevations versus intravitreal injections or implants (100%), potential for longer duration of action versus intravitreal steroid injections or implants (92%), and desire to use a new delivery modality (83%). Nearly all participants (92%) found injection procedure relatively easy post-training, with most (75%) procedurally comfortable after completing 2-5 injections. 58% of participants indicated that their patients gained 2-3 lines of vision by first follow-up visit, and 92% reported having patients who experienced 100-150 μm or greater reduction in central subfield thickness. Overall, 92% of participants were satisfied with SCS-TA treatment outcomes. Findings from this survey of early adopters of SCS-TA indicate that the suprachoroidal injection technique was easy to learn and resulted in favorable patient outcomes consistent with clinical trial data.

摘要

目的

了解医师对于曲安奈德玻璃体内注射(IVTA)治疗葡萄膜炎性黄斑水肿(UME)的真实体验。

结果

对美国的 12 位视网膜/葡萄膜炎专家进行了关于玻璃体内注射(IVTA)手术和患者结局的调查。调查参与者对 243 例不同疾病特征(病因、慢性程度和解剖亚型)的 UME 患者进行了≥291 次玻璃体内注射。采用玻璃体内注射的常见原因包括与玻璃体内注射或植入物相比,降低类固醇相关眼压升高风险(100%)、作用持续时间更长(92%)以及希望采用新的给药方式(83%)。几乎所有参与者(92%)在接受培训后发现注射程序相对简单,大多数参与者(75%)在完成 2-5 次注射后在程序上感到舒适。58%的参与者表示患者在首次随访时视力提高了 2-3 行,92%的参与者报告患者的中央凹下区厚度减少了 100-150μm 或更多。总体而言,92%的参与者对玻璃体内注射的治疗结果感到满意。对玻璃体内注射的早期使用者进行的这项调查结果表明,玻璃体内注射技术易于学习,且患者的结局与临床试验数据一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab27/11515593/1a85931b5de2/13104_2024_6969_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab27/11515593/28035b74a87a/13104_2024_6969_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab27/11515593/1a85931b5de2/13104_2024_6969_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab27/11515593/28035b74a87a/13104_2024_6969_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab27/11515593/1a85931b5de2/13104_2024_6969_Fig2_HTML.jpg

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本文引用的文献

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Ocul Immunol Inflamm. 2024 Sep;32(7):1494-1497. doi: 10.1080/09273948.2023.2232447. Epub 2023 Jul 14.
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Suprachoroidal triamcinolone acetonide for the treatment of macular edema associated with retinal vein occlusion: a pilot study.玻璃体内曲安奈德治疗视网膜静脉阻塞相关黄斑水肿的初步研究。
BMC Ophthalmol. 2023 Feb 10;23(1):60. doi: 10.1186/s12886-023-02808-5.
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Vision Loss in Uveitis.葡萄膜炎所致视力丧失
Ocul Immunol Inflamm. 2021 Aug 18;29(6):1037-1039. doi: 10.1080/09273948.2021.2017152.
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Extension study of the safety and efficacy of CLS-TA for treatment of macular oedema associated with non-infectious uveitis (MAGNOLIA).CLS-TA 治疗非感染性葡萄膜炎相关黄斑水肿的安全性和有效性的扩展研究(MAGNOLIA)。
Br J Ophthalmol. 2022 Aug;106(8):1139-1144. doi: 10.1136/bjophthalmol-2020-317560. Epub 2021 Mar 12.
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Suprachoroidal Delivery of Small Molecules, Nanoparticles, Gene and Cell Therapies for Ocular Diseases.用于眼部疾病的小分子、纳米颗粒、基因和细胞疗法的脉络膜上腔给药
Pharmaceutics. 2021 Feb 22;13(2):288. doi: 10.3390/pharmaceutics13020288.
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Suprachoroidal CLS-TA for non-infectious uveitis: an open-label, safety trial (AZALEA).脉络膜上腔注射CLS-TA治疗非感染性葡萄膜炎:一项开放标签的安全性试验(AZALEA)
Br J Ophthalmol. 2022 Jun;106(6):802-806. doi: 10.1136/bjophthalmol-2020-318019. Epub 2021 Feb 5.
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