Li Fuhao, Huang Fengming, Tang Yulong, Zhang Fan, Jiang Hao, Chen Jun, Lv Bin
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou310006, Zhejiang, People's Republic of China.
Key Laboratory of Digestive Pathophysiology of Zhejiang Province, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hubin Campus, Hangzhou, Zhejiang310006, People's Republic of China.
Br J Nutr. 2024 Nov 28;132(10):1348-1355. doi: 10.1017/S0007114524002368. Epub 2024 Oct 24.
Previous research has suggested a potential link between folic acid (FA) supplementary therapy and gastric ulcers (GU). To investigate this relationship further, we conducted a Mendelian randomisation (MR) analysis using data from the UK Biobank. Our analysis primarily employed inverse-variance weighted (IVW) methods, including both fixed-effect and random-effect models. To ensure the robustness of our findings, additional methods such as the simple median, the weighted median and the penalised weighted median were also applied. The MR analysis aimed to explore the causal effect of FA supplementary therapy on GU. Seven SNP at genetic loci associated with FA supplementary therapy were identified. Both the random-effect and fixed-effect IVW models indicated that genetically predicted FA supplementary therapy significantly reduced the risk of GU (OR, 0·870; 95 % CI 0·826, 0·917, < 0·001). This result was consistent across other methods, with similar outcomes observed using the simple median (OR, 0·835; 95 % CI 0·773, 0·901, < 0·001), the weighted median (OR, 0·854; 95 % CI 0·794, 0·919, < 0·001) and the penalised weighted median (OR, 0·849; 95 % CI 0·789, 0·914, < 0·001). Leave-one-out sensitivity analysis confirmed that no individual SNP significantly drove the association between FA supplementary therapy and GU. This MR study provides genetic evidence that FA supplementary therapy may decrease the risk of GU.
先前的研究表明叶酸（FA）补充疗法与胃溃疡（GU）之间可能存在联系。为了进一步研究这种关系，我们使用英国生物银行的数据进行了孟德尔随机化（MR）分析。我们的分析主要采用逆方差加权（IVW）方法，包括固定效应模型和随机效应模型。为确保研究结果的稳健性，我们还应用了其他方法，如简单中位数法、加权中位数法和惩罚加权中位数法。MR分析旨在探究FA补充疗法对GU的因果效应。我们确定了7个与FA补充疗法相关基因位点的单核苷酸多态性（SNP）。随机效应和固定效应IVW模型均表明，基因预测的FA补充疗法显著降低了GU的风险（比值比[OR]为0.870；95%置信区间[CI]为0.826至0.917，P<0.001）。其他方法得到的结果一致，使用简单中位数法（OR为0.835；95%CI为0.773至0.901，P<0.001）、加权中位数法（OR为0.854；95%CI为0.794至0.919，P<0.001）和惩罚加权中位数法（OR为0.849；95%CI为0.789至0.914，P<0.001）时观察到了类似结果。逐一剔除敏感性分析证实，没有单个SNP显著驱动FA补充疗法与GU之间的关联。这项MR研究提供了基因证据，表明FA补充疗法可能会降低GU的风险。
