• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种新型的 ANG-BSA/BCNU/ICG MNPs 用于胶质母细胞瘤的靶向治疗。

A Novel ANG-BSA/BCNU/ICG MNPs Integrated for Targeting Therapy of Glioblastoma.

机构信息

Department of Radiology, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital,3002 SunGangXi Road, Shenzhen, China.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510282, People's Republic of China.

出版信息

Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241281321. doi: 10.1177/15330338241281321.

DOI:10.1177/15330338241281321
PMID:39444362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11526396/
Abstract

PURPOSE

Develop an albumin nanoparticle-based nanoprobe for targeted glioblastoma (GBM) diagnosis and treatment, utilizing Angopep-2 for low-density lipoprotein receptor-related protein (LRP) targeting.

METHODS

Combined albumin-coated superparamagnetic iron oxide (SPIO), Carmustine (BCNU), and indocyanine green (ICG). Assessed morphology, size, Zeta potential, fluorescence, and drug encapsulation. Conducted in vitro fluorescence/MRI imaging and cell viability assays, and in vivo nanoprobe accumulation evaluation in brain tumors.

RESULTS

ANG-BSA/BCNU/ICG MNPs exhibited superior targeting and cytotoxicity against GBM cells in vitro. In vivo, enhanced brain tumor accumulation during imaging was observed.

CONCLUSION

This targeted imaging and drug delivery system holds promise for efficient GBM therapy and intraoperative localization, addressing Blood-brain barrier (BBB) limitations with precise drug delivery and imaging capabilities.

摘要

目的

开发一种基于白蛋白纳米颗粒的纳米探针，用于靶向脑胶质瘤（GBM）的诊断和治疗，利用 Angopep-2 进行低密度脂蛋白受体相关蛋白（LRP）靶向。

方法

将载有 Angiopep-2 的白蛋白包覆超顺磁性氧化铁（SPIO）、卡莫司汀（BCNU）和吲哚菁绿（ICG）结合在一起。评估形貌、尺寸、Zeta 电位、荧光和药物包封。进行体外荧光/MRI 成像和细胞活力测定，以及体内脑肿瘤中纳米探针的积累评估。

结果

ANG-BSA/BCNU/ICG MNPs 表现出对体外 GBM 细胞的优异靶向性和细胞毒性。在体内，观察到成像期间增强的脑肿瘤积累。

结论

这种靶向成像和药物传递系统有望实现高效的 GBM 治疗和术中定位，通过精确的药物传递和成像能力解决血脑屏障（BBB）的限制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/dd296d030faa/10.1177_15330338241281321-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/e4a4ea280c5a/10.1177_15330338241281321-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/88501f50084a/10.1177_15330338241281321-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/342a2026e0fd/10.1177_15330338241281321-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/66a9da648944/10.1177_15330338241281321-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/fc78baf7bd38/10.1177_15330338241281321-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/a0fd1a4ea418/10.1177_15330338241281321-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/dd296d030faa/10.1177_15330338241281321-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/e4a4ea280c5a/10.1177_15330338241281321-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/88501f50084a/10.1177_15330338241281321-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/342a2026e0fd/10.1177_15330338241281321-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/66a9da648944/10.1177_15330338241281321-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/fc78baf7bd38/10.1177_15330338241281321-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/a0fd1a4ea418/10.1177_15330338241281321-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2887/11526396/dd296d030faa/10.1177_15330338241281321-fig7.jpg

相似文献

1
A Novel ANG-BSA/BCNU/ICG MNPs Integrated for Targeting Therapy of Glioblastoma.一种新型的 ANG-BSA/BCNU/ICG MNPs 用于胶质母细胞瘤的靶向治疗。
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241281321. doi: 10.1177/15330338241281321.
2
Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis.递送FTY720的人参皂苷F2修饰脂质体通过铁死亡增强胶质母细胞瘤靶向性和抗肿瘤活性。
Phytomedicine. 2025 Aug;144:156917. doi: 10.1016/j.phymed.2025.156917. Epub 2025 May 30.
3
Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM).乳酸包被的聚脲-siRNA树枝状复合物：一种针对胶质母细胞瘤（GBM）的基因治疗导向且基于代谢的策略。
Cancer Gene Ther. 2025 Apr 27. doi: 10.1038/s41417-025-00906-8.
4
Breaking Barriers in Glioblastoma Targeting through Advanced Nanoparticle Cell Membrane Coating.通过先进的纳米颗粒细胞膜包被突破胶质母细胞瘤靶向治疗的障碍
ACS Appl Mater Interfaces. 2025 Jun 18;17(24):35288-35303. doi: 10.1021/acsami.5c07306. Epub 2025 Jun 9.
5
Dual-targeting and excretable ultrasmall SPIONs for T-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein.靶向载脂蛋白受体相关蛋白的双靶点可排泄超顺磁性氧化铁纳米粒子用于颅内神经胶质瘤细胞 T1 加权正 MRI 成像
J Mater Chem B. 2020 Mar 18;8(11):2296-2306. doi: 10.1039/c9tb02391g.
6
Intranasal delivery of temozolomide and desloratadine for brain tumour therapy: A cellular study on nasal epithelial toxicity, transport, and permeability.替莫唑胺和地氯雷他定经鼻给药用于脑肿瘤治疗：关于鼻上皮毒性、转运和通透性的细胞研究
J Pharm Sci. 2025 Jul;114(7):103795. doi: 10.1016/j.xphs.2025.103795. Epub 2025 Apr 14.
7
AN in vitro evaluation of a carmustine-loaded Nano-co-Plex for potential magnetic-targeted intranasal delivery to the brain.一种载有卡莫司汀的纳米复合制剂用于潜在磁靶向鼻内给药至脑部的体外评价。
Int J Pharm. 2016 Mar 16;500(1-2):196-209. doi: 10.1016/j.ijpharm.2016.01.043. Epub 2016 Jan 19.
8
Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma.用于共递送靶向miR-21和miR-210的反义寡核苷酸以治疗胶质母细胞瘤的超小纳米颗粒。
J Nanobiotechnology. 2025 Jul 2;23(1):482. doi: 10.1186/s12951-025-03529-1.
9
Bypassing Blood-Brain Barrier and Glucose Dependency of Anti-Glioblastoma Drug Candidates Targeting Mitochondrial Respiration.绕过针对线粒体呼吸的抗胶质母细胞瘤候选药物的血脑屏障和葡萄糖依赖性。
J Cell Physiol. 2025 Jul;240(7):e70062. doi: 10.1002/jcp.70062.
10
Nanostructured lipid carriers for enhanced batimastat delivery across the blood-brain barrier: an in vitro study for glioblastoma treatment.用于增强巴替麦司他透过血脑屏障递送的纳米结构脂质载体：一项针对胶质母细胞瘤治疗的体外研究
Drug Deliv Transl Res. 2025 Jan 6. doi: 10.1007/s13346-024-01775-8.

引用本文的文献

1
Beyond the Walls of Troy: A Scoping Review on Pharmacological Strategies to Enhance Drug Delivery Across the Blood-Brain Barrier and Blood-Tumor Barrier.超越特洛伊城墙：关于增强药物透过血脑屏障和血肿瘤屏障递送的药理学策略的范围综述
Int J Mol Sci. 2025 Jul 22;26(15):7050. doi: 10.3390/ijms26157050.

本文引用的文献

1
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.ARRIVE 指南 2.0：报告动物研究的更新指南。
Br J Pharmacol. 2020 Aug;177(16):3617-3624. doi: 10.1111/bph.15193. Epub 2020 Jul 14.
2
Targeted delivery of etoposide, carmustine and doxorubicin to human glioblastoma cells using methoxy poly(ethylene glycol)‑poly(ε‑caprolactone) nanoparticles conjugated with wheat germ agglutinin and folic acid.使用与麦芽凝集素和叶酸偶联的甲氧基聚乙二醇-聚（ε-己内酯）纳米粒靶向递送至人神经胶质瘤细胞的依托泊苷、卡莫司汀和阿霉素。
Mater Sci Eng C Mater Biol Appl. 2019 Mar;96:114-128. doi: 10.1016/j.msec.2018.10.094. Epub 2018 Nov 4.
3
Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy.
载全氟辛基溴化物和吲哚菁绿的纳米脂质体用于增强多模态成像引导光疗。
Biomaterials. 2018 May;165:1-13. doi: 10.1016/j.biomaterials.2018.02.041. Epub 2018 Feb 24.
4
A Laser-Activated Biocompatible Theranostic Nanoagent for Targeted Multimodal Imaging and Photothermal Therapy.一种用于靶向多模态成像和光热治疗的激光激活生物相容性诊疗纳米剂。
Theranostics. 2017 Oct 6;7(18):4410-4423. doi: 10.7150/thno.21283. eCollection 2017.
5
A new near-infrared persistent luminescence nanoparticle as a multifunctional nanoplatform for multimodal imaging and cancer therapy.一种新型近红外长余辉纳米颗粒作为多功能纳米平台，用于多模态成像和癌症治疗。
Biomaterials. 2018 Jan;152:15-23. doi: 10.1016/j.biomaterials.2017.10.032. Epub 2017 Oct 20.
6
Radioiodine-labeled anti-epidermal growth factor receptor binding bovine serum albumin-polycaprolactone for targeting imaging of glioblastoma.放射性碘标记抗表皮生长因子受体结合牛血清白蛋白-聚己内酯用于胶质母细胞瘤的靶向成像。
Oncol Rep. 2017 Nov;38(5):2919-2926. doi: 10.3892/or.2017.5937. Epub 2017 Sep 4.
7
Investigation of novel superparamagnetic NiZnFeO@albumen nanoparticles for controlled delivery of anticancer drug.新型超顺磁 NiZnFeO@白蛋白纳米粒子用于抗癌药物的控制释放研究。
Nanotechnology. 2017 Sep 8;28(36):365101. doi: 10.1088/1361-6528/aa7d81. Epub 2017 Jul 4.
8
Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization.用于癌症药物递送的人血清白蛋白纳米颗粒：工艺优化与体外表征
Nanomaterials (Basel). 2016 Jun 15;6(6):116. doi: 10.3390/nano6060116.
9
Dual-Targeted Multifunctional Nanoparticles for Magnetic Resonance Imaging Guided Cancer Diagnosis and Therapy.双靶向多功能纳米颗粒用于磁共振成像引导的癌症诊断和治疗。
ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9986-9995. doi: 10.1021/acsami.6b16486. Epub 2017 Mar 10.
10
Topical colloidal indocyanine green-mediated photodynamic therapy for treatment of basal cell carcinoma.局部应用胶体吲哚菁绿介导的光动力疗法治疗基底细胞癌。
Pharm Dev Technol. 2017 Jun;22(4):545-550. doi: 10.3109/10837450.2016.1146294. Epub 2016 Feb 19.