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心脏计算机断层扫描检测纤维脂肪组织浸润:一例致心律失常性心肌病病例

Detection of Fibroadipose Tissue Infiltration with Cardiac Computed Tomography: A Case of Arrhythmogenic Cardiomyopathy.

作者信息

Lassandro Eleonora, Savo Maria Teresa, Martini Marika, Pinci Serena

机构信息

Department of Cardio-Thoracic-Vascular and Public Health, Cardiology Unit, Padova University Hospital, Padova, Italy.

出版信息

J Cardiovasc Echogr. 2024 Jul-Sep;34(3):137-139. doi: 10.4103/jcecho.jcecho_33_24. Epub 2024 Sep 21.

DOI:10.4103/jcecho.jcecho_33_24
PMID:39444385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11495310/
Abstract

In the evaluation of cardiomyopathies, cardiac computed tomography (CCT) is predominantly used for assessing congenital or acquired coronary artery diseases as a potential etiology underlying the observed myocardial abnormalities. However, its utility is expected to expand. We present a case of an asymptomatic patient with claustrophobia who sought medical attention due to frequent ventricular beats. The resting electrocardiogram revealed repolarization abnormalities characterized by flattened T-waves in the lateral leads and low QRS voltages in the peripheral leads, whereas transthoracic echocardiography was normal. CCT accurately identified hypodense areas indicative of fibrofatty infiltration within the inferolateral and anterior walls of the left ventricle. Furthermore, late iodine contrast-phase imaging revealed subepicardial late enhancement striae in the same regions. These imaging findings were pivotal in establishing a diagnosis of left-dominant arrhythmogenic cardiomyopathy. This clinical vignette underscores the potential of CCT in tissue characterization, particularly when cardiac magnetic resonance imaging is contraindicated or unavailable.

摘要

在心肌病的评估中,心脏计算机断层扫描(CCT)主要用于评估先天性或后天性冠状动脉疾病,作为观察到的心肌异常的潜在病因。然而,其用途有望扩大。我们报告一例患有幽闭恐惧症的无症状患者,因频发室性早搏前来就医。静息心电图显示复极异常,表现为侧壁导联T波低平,外周导联QRS波电压降低,而经胸超声心动图正常。CCT准确识别出左心室下外侧壁和前壁内提示纤维脂肪浸润的低密度区域。此外,延迟碘造影期成像显示相同区域的心外膜下延迟强化条纹。这些影像学表现对于确立左优势型致心律失常性心肌病的诊断至关重要。这个临床病例强调了CCT在组织特征描述方面的潜力,特别是在心脏磁共振成像禁忌或无法进行时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/d8aaf6f6d222/JCE-34-137-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/110e173e1afb/JCE-34-137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/9fdf26b6fd5c/JCE-34-137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/d8aaf6f6d222/JCE-34-137-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/110e173e1afb/JCE-34-137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/9fdf26b6fd5c/JCE-34-137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b384/11495310/d8aaf6f6d222/JCE-34-137-g003.jpg

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本文引用的文献

1
Phenotypic Expression and Clinical Outcomes in Patients With Arrhythmogenic Cardiomyopathies.致心律失常性右室心肌病患者的表型表达和临床结局。
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Eur Heart J. 2023 Oct 1;44(37):3503-3626. doi: 10.1093/eurheartj/ehad194.
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Clinical profile and long-term follow-up of a cohort of patients with desmoplakin cardiomyopathy.特发性心肌致密化不全的临床特征和长期随访结果。
Heart Rhythm. 2022 Aug;19(8):1315-1324. doi: 10.1016/j.hrthm.2022.04.015. Epub 2022 Apr 22.
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Clinical applications of cardiac computed tomography: a consensus paper of the European Association of Cardiovascular Imaging-part II.心脏计算机断层扫描的临床应用:欧洲心血管影像协会共识文件第二部分。
Eur Heart J Cardiovasc Imaging. 2022 Mar 22;23(4):e136-e161. doi: 10.1093/ehjci/jeab292.
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Epicardial Fat Distribution Assessed with Cardiac CT in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.心脏 CT 评估致心律失常性右室心肌病/发育不良的心外膜脂肪分布。
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MR and CT imaging of Arrhythmogenic Cardiomyopathy.致心律失常性心肌病的磁共振成像和计算机断层扫描成像
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Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity.左优势型致心律失常性心肌病:一种未被充分认识的临床实体。
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