Bohac Maja, Gilevska Fanka, Biscevic Alma, Gabric Ivan, Gabric Kresimir, Patel Sudi
Specialty Eye Hospital Svjetlost, School of Medicine, University of Rijeka, Zagreb, Croatia.
Eye Clinic Sistina Oftalmologija, Skopje, North Macedonia.
J Ophthalmol. 2024 Oct 15;2024:8827837. doi: 10.1155/2024/8827837. eCollection 2024.
To determine if cross-linking (CXL) treatment modifies any pre-existing association between corneal optical density (COD) and age in keratoconus free of corneal scarring. COD was monitored in two groups (i) before and after standard CXL treatment for keratoconus (de-epithelization with a crescent blade, = 69 eyes) and (ii) age/gender-matched cases without any signs of keratoconus ( = 24 eyes). Seven different markers of COD were quantified using a 0-100 grey scale, supplied with Pentacam™ software. Mean age (±sd, range) in Group I (19 females and 50 males) was 24.2 years (±7.2, 11-44) and in Group II (9 females and 15 males), it was 24.7 years (±7.6, 17-45). COD over the apex and along the depth of the cornea (y, arbitrary scale units) was associated with age (, in years) in Group I at preop ( = 0.08 + 13.12, = 0.350 and =0.003), at 12 months postop ( = 0.08 + 15.15, = 0.295 and =0.014) and in Group II, at the start ( = 0.16 + 11.28, = 0.474 and =0.019) and 12 months later ( = 0.24 + 8.63, = 0.600 and =0.002). The change in COD following CXL was significantly associated with the preop value. CXL initially breaks down the pre-existing relationship between COD and age. This is re-established by 12 months postop. The CXL induced change in COD depends on the preop value but not on the patient's age.
为了确定交联（CXL）治疗是否会改变无角膜瘢痕的圆锥角膜中角膜光学密度（COD）与年龄之间任何已有的关联。对两组进行了COD监测：（i）圆锥角膜标准CXL治疗前后（用新月形刀片去除上皮，n = 69只眼）；（ii）年龄/性别匹配的无圆锥角膜任何体征的病例（n = 24只眼）。使用Pentacam™软件提供的0-100灰度标度对七种不同的COD标记物进行定量。第一组（19名女性和50名男性）的平均年龄（±标准差，范围）为24.2岁（±7.2，11-44岁），第二组（9名女性和15名男性）为24.7岁（±7.6，17-45岁）。第一组术前（y = 0.08x + 13.12，r = 0.350，p = 0.003）、术后12个月（y = 0.08x + 15.15，r = 0.295，p = 0.014）以及第二组开始时（y = 0.16x + 11.28，r = 0.474，p = 0.019）和12个月后（y = 0.24x + 8.63，r = 0.600，p = 0.
