Villafranco Javier, Martínez-Ramírez Gabriela, Magaña-Maldonado Roxana, González-Ruvalcaba Anna Paola, López-Ornelas Adolfo, Velasco Iván, Becerril-Villanueva Enrique, Pavón Lenin, Estudillo Enrique, Pérez-Sánchez Gilberto
Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, Mexico.
Laboratorio de Psicoinmunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñíz, Ciudad de México, Mexico.
Front Psychiatry. 2024 Oct 9;15:1470642. doi: 10.3389/fpsyt.2024.1470642. eCollection 2024.
The neurobiological mechanisms underlying major depressive disorder (MDD) remain largely unexplored due to the limited availability of study models in humans. Induced pluripotent stem cells (iPSCs) have overcome multiple limitations of retrospective clinical studies, contributing to a more detailed understanding of the molecular pathways that presumably contribute to the manifestation of depression. Despite the significant progress made by these study models, there are still more formidable challenges that will eventually be addressed by these platforms, as further studies may eventually emerge. This review will examine the most recent advances in the comprehension of depression by using human neurons and non-neuronal cells derived from induced pluripotent stem cells of patients with depression. This study highlights the importance of using these platforms to increase our knowledge of depression and address this psychiatric disorder more efficiently.
由于人类研究模型的可用性有限，重度抑郁症（MDD）背后的神经生物学机制在很大程度上仍未得到探索。诱导多能干细胞（iPSC）克服了回顾性临床研究的多重局限性，有助于更详细地了解可能导致抑郁症表现的分子途径。尽管这些研究模型取得了重大进展，但仍有更严峻的挑战最终将由这些平台解决，因为可能会出现进一步的研究。本综述将通过使用源自抑郁症患者诱导多能干细胞的人类神经元和非神经元细胞，来审视在抑郁症理解方面的最新进展。这项研究强调了利用这些平台来增加我们对抑郁症的认识并更有效地应对这种精神疾病的重要性。
