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迷迭香酸的化学保护兴奋效应。

The chemoprotective hormetic effects of rosmarinic acid.

作者信息

Calabrese Edward J, Pressman Peter, Hayes A Wallace, Dhawan Gaurav, Kapoor Rachna, Agathokleous Evgenios, Baldwin Linda A, Calabrese Vittorio

机构信息

School of Public Health and Health Sciences, Department of Environmental Health Sciences, Morrill I-N344, University of Massachusetts, Amherst, MA, 01003, United States of America.

University of Maine, Orono, ME, 04469, United States of America.

出版信息

Open Med (Wars). 2024 Oct 21;19(1):20241065. doi: 10.1515/med-2024-1065. eCollection 2024.

DOI:10.1515/med-2024-1065
PMID:39444791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11497216/
Abstract

Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints. Consequently, this article provides the first assessment of rosmarinic acid-induced hormetic concentration/dose responses, their quantitative features, mechanistic foundations, extrapolative strengths/limitations, and their biomedical, clinical, and public health implications.

摘要

迷迭香酸是一种存在于多种水果和蔬菜中的多酚，人们会以补充剂形式摄入它，并且由于其假定的化学预防特性，它在众多治疗应用的临床试验中接受了测试。迷迭香酸已在细胞、整体动物和分子机制水平上得到广泛研究，呈现出一系列复杂的多系统生物学效应。迷迭香酸诱导的兴奋效应剂量反应广泛存在，在众多生物学模型和细胞类型中针对广泛的终点指标都有出现。因此，本文首次评估了迷迭香酸诱导的兴奋效应浓度/剂量反应、它们的定量特征、机制基础、外推优势/局限性，以及它们对生物医学、临床和公共卫生的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3863/11497216/00c172e94bf1/j_med-2024-1065-fig018.jpg
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本文引用的文献

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Hormetic Nutrition and Redox Regulation in Gut-Brain Axis Disorders.肠道-脑轴疾病中的应激性营养与氧化还原调节
Antioxidants (Basel). 2024 Apr 18;13(4):484. doi: 10.3390/antiox13040484.
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Plasma Concentrations of Rosmarinic Acid in Patients on Antiretroviral Therapy: In Silico Exploration Based on Clinical Data.抗逆转录病毒治疗患者血浆迷迭香酸浓度：基于临床数据的计算探索。
Int J Mol Sci. 2024 Feb 13;25(4):2230. doi: 10.3390/ijms25042230.
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Impact of hormesis to deepen our understanding of the mechanisms underlying the bioactivities of polyphenols.
兴奋效应有助于深化我们对多酚生物活性潜在机制的理解。
Curr Opin Biotechnol. 2024 Apr;86:103074. doi: 10.1016/j.copbio.2024.103074. Epub 2024 Feb 6.
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Effects of rosmarinic acid and doxorubicine on an ovarian adenocarsinoma cell line (OVCAR3) via the EGFR pathway.迷迭香酸和阿霉素通过 EGFR 通路对卵巢腺癌细胞系（OVCAR3）的影响。
Acta Cir Bras. 2024 Feb 5;39:e390524. doi: 10.1590/acb390524. eCollection 2024.
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Hormesis determines lifespan.毒物兴奋效应决定寿命。
Ageing Res Rev. 2024 Feb;94:102181. doi: 10.1016/j.arr.2023.102181. Epub 2024 Jan 3.
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The Effect of Rosmarinus Officinalis as a Potential Root Canal Medication on the Viability of Dental Pulp Stem Cells.迷迭香作为一种潜在的根管药物对牙髓干细胞活力的影响。
J Contemp Dent Pract. 2023 Sep 1;24(9):623-631. doi: 10.5005/jp-journals-10024-3570.
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Hormesis defines the limits of lifespan.毒物兴奋效应决定了寿命的极限。
Ageing Res Rev. 2023 Nov;91:102074. doi: 10.1016/j.arr.2023.102074. Epub 2023 Sep 13.
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Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies.迷迭香酸通过何种分子机制对神经退行性变及其他中枢神经系统病变发挥神经保护作用。
Phytother Res. 2023 May;37(5):2119-2143. doi: 10.1002/ptr.7825. Epub 2023 Apr 4.
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Evaluation of Rosmarinic Acid on Broiler Growth Performance, Serum Biochemistry, Liver Antioxidant Activity, and Muscle Tissue Composition.迷迭香酸对肉鸡生长性能、血清生化指标、肝脏抗氧化活性及肌肉组织成分的影响评估
Animals (Basel). 2022 Nov 27;12(23):3313. doi: 10.3390/ani12233313.
10
Hormesis: wound healing and fibroblasts.胁迫效应：创伤愈合与成纤维细胞
Pharmacol Res. 2022 Oct;184:106449. doi: 10.1016/j.phrs.2022.106449. Epub 2022 Sep 14.