Impact of hormesis to deepen our understanding of the mechanisms underlying the bioactivities of polyphenols.

Cells, organs, and the whole body are continuously exposed to various types of stressors, including oxidative stress, protein denaturation, hypoxia, energy starvation, and pathogen insults. Hormesis is an adaptive phenomenon in which a stressor induces cellular stress responses at low or moderate doses, while catastrophic damage is manifested at high doses. Polyphenols, as xenobiotic phytochemicals, exhibit stress responses in animal cells, as demonstrated in cellular and rodent models. In this review article, the author highlighted several molecular mechanisms underlying different types of stress adaptation and hormetic phenomena induced by bioactive polyphenols to substantially understand how and why those phytochemicals function in biological systems.