Wang Xinzheng, Wu Lifei, Zhou Huifen, He Jiandong
Department of Physical Education, Zhejiang Chinese Medical University, Hangzhou, China.
College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Front Aging Neurosci. 2024 Oct 9;16:1455546. doi: 10.3389/fnagi.2024.1455546. eCollection 2024.
This study investigates the associations and mediating pathways between grip strength, cognitive function, and depression in middle-aged and elderly individuals in China.
Utilizing data from the 2011 China Health and Retirement Longitudinal Study (CHARLS), we employed logistic regression and mediation analysis to examine the relationships and mediating factors between grip strength, cognitive function, and depression, while adjusting for potential confounders.
The study included 6,841 participants, of whom 1,734 (25.35%) exhibited symptoms of depression. Our findings indicate that weak grip strength is significantly associated with an increased risk of depression (OR: 1.57, 95% CI: 1.32-1.87) among the middle-aged and elderly population. Conversely, good cognitive function was found to be protective against depression (OR: 0.94, 95% CI: 0.93-0.95). Grip strength indirectly affected depression through cognitive function, accounting for 9.4% of the total effect ( = -0.008, 95% CI [-0.013, -0.004]). This mediating effect was 23.8% in men ( = -0.013, 95% CI [-0.020, -0.007]); and 23.2% in those aged 60 years and over ( = -0.015, 95% CI [-0.022, -0.009]).
This study highlights that weak grip strength increases risk of depressive symptoms, and adequate cognitive function can mitigate the association between weak grip strength and an increased risk of depression among middle-aged and elderly individuals in China. Psychological care for elder adults with weak grip strength and poor cognitive function should be strengthened.
本研究调查中国中老年人握力、认知功能和抑郁之间的关联及中介途径。
利用2011年中国健康与养老追踪调查（CHARLS）的数据，我们采用逻辑回归和中介分析来检验握力、认知功能和抑郁之间的关系及中介因素，同时对潜在混杂因素进行了调整。
该研究纳入了6841名参与者，其中1734名（25.35%）表现出抑郁症状。我们的研究结果表明，在中国中老年人群中，握力弱与抑郁风险增加显著相关（比值比：1.57，95%置信区间：1.32 - 1.87）。相反，良好的认知功能被发现可预防抑郁（比值比：0.94，95%置信区间：0.93 - 0.95）。握力通过认知功能间接影响抑郁，占总效应的9.4%（β = -0.008，95%置信区间[-0.013, -0.004]）。这种中介效应在男性中为23.8%（β = -0.013，95%置信区间[-0.020, -0.007]）；在60岁及以上人群中为23.2%（β = -0.015，95%置信区间[-0.022, -0.009]）。
本研究强调握力弱会增加抑郁症状的风险，而适当的认知功能可以减轻中国中老年人握力弱与抑郁风险增加之间的关联。应加强对握力弱且认知功能差的老年人的心理关怀。
