Kim Eric S, Kawachi Ichiro, Chen Ying, Kubzansky Laura D
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Lee Kum Sheung Center for Health and Happiness, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAMA Psychiatry. 2017 Oct 1;74(10):1039-1045. doi: 10.1001/jamapsychiatry.2017.2145.
Higher purpose in life is hypothesized to reduce the likelihood of developing weak grip strength and slow walking speed because purpose has been linked with a range of positive health behaviors and biological processes that are potentially protective against declining physical function. However, the association between purpose in life and objective physical function has not been examined.
To assess whether higher purpose in life among adequately functioning older adults is associated with lower risk of developing weak grip strength and slow walking speed over time.
DESIGN, SETTING, AND PARTICIPANTS: Data for a longitudinal cohort study were collected in 2006 and again in 2010 from the Health and Retirement Study, a nationally representative study of US adults older than 50 years. Data analysis was conducted from November 23, 2016, to June 2, 2017.
The risk of developing weak grip strength (assessed as a binary yes or no outcome) or slow walking speed (yes or no) during the 4-year follow-up period. Grip strength was assessed using Smedley spring-type hand dynamometers, and walking speed was assessed by asking respondents to walk 2.5 m at their normal walking pace.
In this study, 4486 adults had grip scores at baseline indicating adequate function (2665 women and 1821 men; mean [SD] age, 63.0 [8.2] years) and 1461 adults had walking scores at baseline indicating adequate function (801 women and 660 men; mean [SD] age, 70.8 [6.5] years). After controlling for sociodemographic factors, each 1-SD increase in purpose was associated with a 13% decreased risk (95% CI, 1%-23%) of developing weak grip strength and a 14% decreased risk (95% CI, 8%-20%) of developing slow walking speed. Associations with walking speed were maintained in all covariate models (fully adjusted model: risk ratio, 0.89; 95% CI, 0.83-0.95), but associations with grip strength did not reach conventional levels of statistical significance after additionally adjusting for relevant baseline health factors, depressive symptoms, and health behaviors (fully adjusted model: risk ratio, 0.91; 95% CI, 0.80-1.04).
Purpose in life was prospectively associated with a decreased risk of developing weak grip strength and slow walking speed, although the findings were more robust for walking speed than for grip strength. These findings suggest that a sense of purpose in life, a modifiable factor, may play an important role in maintaining physical function among older adults.
生活中有更高目标被假定可降低握力变弱和步速变慢的可能性,因为目标已与一系列积极的健康行为和生物过程相关联,这些行为和过程可能对身体机能下降具有保护作用。然而,生活目标与客观身体机能之间的关联尚未得到研究。
评估在功能良好的老年人中,更高的生活目标是否与随着时间推移握力变弱和步速变慢的风险降低相关。
设计、背景和参与者:纵向队列研究的数据于2006年收集,并于2010年再次从健康与退休研究中获取,该研究是一项针对50岁以上美国成年人的全国代表性研究。数据分析于2016年11月23日至2017年6月2日进行。
在4年随访期内握力变弱(评估为二元的是或否结局)或步速变慢(是或否)的风险。握力使用斯梅德利弹簧式握力计进行评估,步速通过要求受访者以正常步行速度行走2.5米来评估。
在本研究中,4486名成年人在基线时握力得分表明功能良好(2665名女性和1821名男性;平均[标准差]年龄,63.0[8.2]岁),1461名成年人在基线时步速得分表明功能良好(801名女性和660名男性;平均[标准差]年龄,70.8[6.5]岁)。在控制了社会人口学因素后,目标每增加1个标准差,握力变弱的风险降低13%(95%置信区间,1%-23%),步速变慢的风险降低14%(95%置信区间,8%-20%)。与步速的关联在所有协变量模型中均保持(完全调整模型:风险比,0.89;95%置信区间,0.83-0.95),但在进一步调整相关基线健康因素、抑郁症状和健康行为后,与握力的关联未达到传统的统计学显著水平(完全调整模型:风险比,0.91;95%置信区间,0.80-1.04)。
生活目标与握力变弱和步速变慢的风险降低存在前瞻性关联,尽管步速方面的研究结果比握力方面更可靠。这些发现表明,生活目标感作为一个可改变的因素,可能在维持老年人身体机能方面发挥重要作用。