The globally distributed health impacts of environmental degradation and widening population inequalities require a fundamental shift in understandings of healthy urbanism - including policies and decisions that shape neighbourhood and building design. The built environment tends to disadvantage or exclude women, children, the elderly, disabled, poor and other groups, starting from design and planning stages through to occupation, and this results in avoidable health impacts. Although these concepts are not new, they are rapidly emerging as built environment research and practice priorities without clear understanding of the interconnected aims of healthy environments that are sustainable, equitable and inclusive. This article promotes a new framework - Towards Healthy uRbanism: InclusiVe Equitable Sustainable (THRIVES) - that extends previous conceptualisations and reorients focus towards the existential threat of environmental breakdown and the social injustice created through inequitable and exclusive urban governance and design processes and outcomes. The Framework was developed through synthesising knowledge from research and practice, and by testing this new conceptualisation in a participatory workshop. Ongoing research is exploring implementation of the Framework in practice. If widely adopted, this Framework may contribute towards achieving the goals of sustainable development through a focus on increasing human health and wellbeing in urban development.