School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Front Immunol. 2024 Oct 9;15:1461919. doi: 10.3389/fimmu.2024.1461919. eCollection 2024.
Macrophage-myofibroblast transformation (MMT) has emerged as a discovery in the field of fibrotic disease research. MMT is the process by which macrophages differentiate into myofibroblasts, leading to organ fibrosis following organ damage and playing an important role in fibrosis formation and progression. Recently, many new advances have been made in studying the mechanisms of MMT occurrence in fibrotic diseases. This article reviews some critical recent findings on MMT, including the origin of MMT in myofibroblasts, the specific mechanisms by which MMT develops, and the mechanisms and effects of MMT in the kidneys, lungs, heart, retina, and other fibrosis. By summarizing the latest research related to MMT, this paper provides a theoretical basis for elucidating the mechanisms of fibrosis in various organs and developing effective therapeutic targets for fibrotic diseases.
巨噬细胞-肌成纤维细胞转化（MMT）的发现是纤维化疾病研究领域的一项重大突破。MMT 是指巨噬细胞分化为肌成纤维细胞的过程，导致器官损伤后发生纤维化，并在纤维化形成和进展中发挥重要作用。最近，在研究纤维化疾病中 MMT 发生的机制方面取得了许多新的进展。本文综述了 MMT 发生的一些关键的最新研究发现，包括肌成纤维细胞中 MMT 的起源、MMT 发生的具体机制，以及 MMT 在肾脏、肺部、心脏、视网膜等纤维化中的机制和作用。通过总结与 MMT 相关的最新研究，本文为阐明各器官纤维化的机制和开发纤维化疾病的有效治疗靶点提供了理论依据。
