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驾驭结节病:在初级保健中识别、管理和支持患者。

Navigating sarcoidosis: Recognizing, managing, and supporting patients in primary care.

机构信息

Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Interstitial Lung Disease (ILD) Center of Excellence, Department of Respiratory Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

Eur J Gen Pract. 2024 Dec;30(1):2418307. doi: 10.1080/13814788.2024.2418307. Epub 2024 Oct 24.

DOI:10.1080/13814788.2024.2418307
PMID:39445489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11504428/
Abstract

BACKGROUND

Sarcoidosis is a chronic multisystem inflammatory disease of unknown aetiology, characterised by noncaseating granulomas and a variable clinical presentation. Despite its global distribution, sarcoidosis is relatively rare, with the highest prevalence in northern Europe. This poses challenges for primary care physicians due to its broad spectrum of symptoms, from organ-specific manifestations to general complaints like fatigue and concentration difficulties.

OBJECTIVES

This article aims to provide primary care physicians with practical tools for the early recognition and management of sarcoidosis, emphasising their role in monitoring disease progression and providing supportive care.

METHODS

Key strategies for diagnosis and management are reviewed, focusing on holistic patient care addressing both somatic and psychosocial aspects of the disease.

RESULTS

Early recognition, careful monitoring of disease progression, and individualised treatment plans are crucial. Pharmacotherapy is not always required and should be carefully balanced. The role of supportive, patient-centered counseling is illustrated with two cases.

CONCLUSION

Primary care physicians play a critical role in managing sarcoidosis, particularly in early recognition and monitoring. Given the absence of standardised treatment protocols, a flexible, holistic approach that includes psychosocial support is essential. This article provides a practical framework for general practitioners to address the challenges of sarcoidosis management and improve patient outcomes.

摘要

背景

结节病是一种病因不明的慢性多系统炎症性疾病,其特征是非干酪样肉芽肿和多变的临床表现。尽管结节病分布广泛,但它相对较少见,北欧的发病率最高。由于其症状谱广泛,从器官特异性表现到疲劳和注意力集中困难等一般症状,这给初级保健医生带来了挑战。

目的

本文旨在为初级保健医生提供早期识别和管理结节病的实用工具,强调他们在监测疾病进展和提供支持性护理方面的作用。

方法

回顾了诊断和管理的关键策略,重点关注整体患者护理,解决疾病的躯体和心理社会方面。

结果

早期识别、仔细监测疾病进展和个体化治疗计划至关重要。并非总是需要药物治疗,应谨慎平衡。通过两个病例说明了支持性、以患者为中心的咨询的作用。

结论

初级保健医生在管理结节病方面发挥着关键作用,特别是在早期识别和监测方面。鉴于缺乏标准化的治疗方案,需要采用灵活的整体方法,包括心理社会支持。本文为全科医生提供了一个实用的框架,以应对结节病管理的挑战并改善患者的结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/dd8a8b88c831/IGEN_A_2418307_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/52a74cda6925/IGEN_A_2418307_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/b336abd8d25d/IGEN_A_2418307_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/dd8a8b88c831/IGEN_A_2418307_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/52a74cda6925/IGEN_A_2418307_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/b336abd8d25d/IGEN_A_2418307_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f55/11504428/dd8a8b88c831/IGEN_A_2418307_F0003_B.jpg

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Lancet Respir Med. 2024 Nov;12(11):848-851. doi: 10.1016/S2213-2600(24)00297-2. Epub 2024 Oct 16.
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Airborne occupational exposures associated with pulmonary sarcoidosis: a systematic review and meta-analysis.与肺结节病相关的空气传播职业暴露:一项系统评价和荟萃分析。
Occup Environ Med. 2023 Oct;80(10):580-589. doi: 10.1136/oemed-2022-108632. Epub 2023 Aug 28.
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The Management of Sarcoidosis in the 2020s by the Primary Care Physician.
《初级保健医生在 21 世纪 20 年代对结节病的管理》。
Am J Med. 2023 Jun;136(6):534-544. doi: 10.1016/j.amjmed.2023.02.014. Epub 2023 Mar 6.
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Sarcoidosis: Epidemiology and clinical insights.结节病:流行病学和临床见解。
J Intern Med. 2023 Jun;293(6):668-680. doi: 10.1111/joim.13629. Epub 2023 Mar 14.
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Long COVID: major findings, mechanisms and recommendations.长新冠:主要发现、机制和建议。
Nat Rev Microbiol. 2023 Mar;21(3):133-146. doi: 10.1038/s41579-022-00846-2. Epub 2023 Jan 13.
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Online mindfulness-based cognitive therapy for fatigue in patients with sarcoidosis (TIRED): a randomised controlled trial.在线正念认知疗法治疗结节病患者疲劳(TIRED):一项随机对照试验。
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Drug-induced comorbidities in patients with sarcoidosis.药物诱导的结节病患者共病。
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Challenges of Sarcoidosis and Its Management.结节病的挑战及其管理
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Misconceptions regarding symptoms of sarcoidosis.关于结节病症状的误解。
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