Deubel V, Digoutte J P, Monath T P, Girard M
J Gen Virol. 1986 Jan;67 ( Pt 1):209-13. doi: 10.1099/0022-1317-67-1-209.
Isolates of yellow fever (YF) virus from Africa (Senegambia, Central African Republic, Ivory Coast, Burkina Faso) and from South America (Panama, Ecuador, Trinidad) were examined by oligonucleotide fingerprinting of the 40S genome RNA. Geographically isolated and epidemiologically unrelated viruses were very distinct. On the basis of the T1 oligonucleotide fingerprints of each isolate, four geographical variants (topotypes) of YF virus isolated within the same period of time have been established. The Ivory Coast and Burkina Faso topotypes were similar. In the Central African Republic, two variants could be found exhibiting 70 to 75% homology to one another. In South America, the three analysed strains exhibited only about 70% homology, but could be classified in the same topotype. The oligonucleotide fingerprints of the genome RNA offered a useful tool for the understanding of YF virus variability.
通过对40S基因组RNA进行寡核苷酸指纹图谱分析，对来自非洲（塞内冈比亚、中非共和国、象牙海岸、布基纳法索）和南美洲（巴拿马、厄瓜多尔、特立尼达）的黄热病（YF）病毒分离株进行了检测。地理上隔离且流行病学上不相关的病毒差异很大。根据每个分离株的T1寡核苷酸指纹图谱，已确定了在同一时期内分离出的YF病毒的四个地理变种（拓扑型）。象牙海岸和布基纳法索的拓扑型相似。在中非共和国，可以发现两个变种彼此之间具有70%至75%的同源性。在南美洲，分析的三个毒株仅表现出约70%的同源性，但可归为同一拓扑型。基因组RNA的寡核苷酸指纹图谱为了解YF病毒的变异性提供了一个有用的工具。
