Suzuki S, Kimura T, Saneyoshi M
J Gen Virol. 1986 Feb;67 ( Pt 2):405-8. doi: 10.1099/0022-1317-67-2-405.
A DNA polymerase induced by Oncorhynchus masou virus (OMV) was isolated from cultured salmon cells infected with OMV using sequential ion-exchange column chromatography steps. The properties of the OMV polymerase were compared to those of human cytomegalovirus (HCMV) polymerase and polymerase alpha from cherry salmon (masu salmon, O. masou) testes. OMV polymerase was clearly distinguished from the other polymerases by its optimum temperature for enzyme activity, 25 degrees C. In an investigation of the effects of phosphonoacetic acid and aphidicolin, OMV polymerase was found to be more resistant to both drugs than HCMV polymerase.
通过连续离子交换柱色谱步骤，从感染了马苏大马哈鱼病毒（OMV）的培养鲑鱼细胞中分离出一种由OMV诱导的DNA聚合酶。将OMV聚合酶的特性与人类巨细胞病毒（HCMV）聚合酶以及樱鳟（马苏大马哈鱼，O. masou）睾丸中的聚合酶α的特性进行了比较。OMV聚合酶因其酶活性的最适温度为25℃而与其他聚合酶明显区分开来。在对膦甲酸和阿非科林作用的研究中，发现OMV聚合酶比HCMV聚合酶对这两种药物更具抗性。
