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1
Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus.人巨细胞病毒膦甲酸钠抗性突变体的分离与鉴定
J Virol. 1987 Apr;61(4):1291-5. doi: 10.1128/JVI.61.4.1291-1295.1987.
2
Isolation and preliminary characterization of a phosphonoacetic acid-resistant and temperature-sensitive mutant of herpes simplex virus type 1.1型单纯疱疹病毒膦酰乙酸抗性和温度敏感突变体的分离与初步鉴定
J Virol. 1982 Apr;42(1):20-9. doi: 10.1128/JVI.42.1.20-29.1982.
3
Characterization of human cytomegalovirus-induced DNA polymerase and the associated 3'-to-5', exonuclease.人巨细胞病毒诱导的DNA聚合酶及相关3'至5'外切核酸酶的特性分析
Virology. 1983 Jan 30;124(2):221-31. doi: 10.1016/0042-6822(83)90339-2.
4
Reversion of mutations in the thymidine kinase gene in herpes simplex viruses resistant to phosphonoacetate.对磷酰乙酸耐药的单纯疱疹病毒中胸苷激酶基因突变的回复突变
Can J Microbiol. 1984 May;30(5):560-4. doi: 10.1139/m84-084.
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Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.对膦甲酸和膦乙酸耐药的疱疹病毒突变体的特征
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Selection for temperature-sensitive mutations in specific vaccinia virus genes: isolation and characterization of a virus mutant which encodes a phosphonoacetic acid-resistant, temperature-sensitive DNA polymerase.特定痘苗病毒基因中温度敏感突变的筛选：一种编码耐膦酰乙酸、温度敏感型DNA聚合酶的病毒突变体的分离与鉴定
Virology. 1983 Jul 30;128(2):444-57. doi: 10.1016/0042-6822(83)90269-6.
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Genetic evidence for vaccinia virus-encoded DNA polymerase: isolation of phosphonoacetate-resistant enzyme from the cytoplasm of cells infected with mutant virus.痘苗病毒编码的DNA聚合酶的遗传学证据：从感染突变病毒的细胞胞质中分离出对磷乙酸耐药的酶。
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Isolation of drug resistant mutants of varicella-zoster virus: cross resistance of acyclovir resistant mutants with phosphonoacetic acid and bromodeoxyuridine.水痘带状疱疹病毒耐药突变体的分离：阿昔洛韦耐药突变体对膦甲酸钠和溴脱氧尿苷的交叉耐药性
Biken J. 1983 Mar;26(1):17-23.
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Susceptibilities of phosphonoacetic acid and acyclovir resistant varicella-zoster virus mutants to 9-beta-arabinofuranosyladenine and 1-beta-arabinofuranosylcytosine.膦甲酸钠和阿昔洛韦耐药的水痘带状疱疹病毒突变体对9-β-D-阿拉伯呋喃糖基腺嘌呤和1-β-D-阿拉伯呋喃糖基胞嘧啶的敏感性。
Biken J. 1986 Mar;29(1):11-7.

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Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.DNA聚合酶中的单个氨基酸变化赋予膦甲酸钠抗性和生长缓慢表型，而在从艾滋病患者中分离出的三株双重耐药人巨细胞病毒株中，UL97编码的磷酸转移酶中的突变赋予更昔洛韦抗性。
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7
Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents.人巨细胞病毒DNA聚合酶基因中的点突变导致对抗病毒药物产生耐药性。
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本文引用的文献

1
Physical mapping of human cytomegalovirus genes: identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide.人类巨细胞病毒基因的物理图谱：编码71 kDa病毒体磷蛋白和病毒65 kDa多肽的DNA序列的鉴定。
Virology. 1984 Apr 15;134(1):91-102. doi: 10.1016/0042-6822(84)90275-7.
2
Single mutations at many sites within the DNA polymerase locus of herpes simplex viruses can confer hypersensitivity to aphidicolin and resistance to phosphonoacetic acid.单纯疱疹病毒DNA聚合酶基因座内许多位点的单突变可导致对阿非科林超敏并对膦甲酸耐药。
J Gen Virol. 1984 Jan;65 ( Pt 1):1-17. doi: 10.1099/0022-1317-65-1-1.
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Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.单纯疱疹病毒DNA聚合酶基因座突变的精细定位与分子克隆
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Structural analysis of the major immediate early gene of human cytomegalovirus.人类巨细胞病毒主要立即早期基因的结构分析
J Virol. 1984 Jan;49(1):190-9. doi: 10.1128/JVI.49.1.190-199.1984.
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Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.单纯疱疹病毒DNA聚合酶基因中赋予对阿非科林超敏反应的突变。
Nucleic Acids Res. 1983 Aug 11;11(15):5287-97. doi: 10.1093/nar/11.15.5287.
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Organization and expression of the immediate early genes of human cytomegalovirus.人巨细胞病毒即刻早期基因的组织与表达
J Virol. 1983 Apr;46(1):1-14. doi: 10.1128/JVI.46.1.1-14.1983.
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Resistance of herpes simplex virus to adenine arabinoside and E-5-(2-bromovinyl)-2'-deoxyuridine: a physical analysis.单纯疱疹病毒对阿糖腺苷和E-5-（2-溴乙烯基）-2'-脱氧尿苷的抗性：一项物理分析。
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8
Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.对一组在膦甲酸存在下选择用于生长的单纯疱疹病毒I型变体诱导产生的DNA聚合酶的特性分析。
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Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.单纯疱疹病毒DNA聚合酶基因的突变可赋予对9-β-D-阿拉伯呋喃糖基腺嘌呤的抗性。
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Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.1型单纯疱疹病毒的阿昔洛韦耐药突变体表现出DNA聚合酶改变或阿昔洛韦磷酸化活性降低。
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人巨细胞病毒膦甲酸钠抗性突变体的分离与鉴定

Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus.

作者信息

D'Aquila R T, Summers W C

出版信息

J Virol. 1987 Apr;61(4):1291-5. doi: 10.1128/JVI.61.4.1291-1295.1987.

DOI:10.1128/JVI.61.4.1291-1295.1987
PMID:3029427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254097/
Abstract

Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.

摘要

分离出了对膦甲酸的抗性比野生型人巨细胞病毒（HCMV，汤氏株）高6至13倍的人巨细胞病毒突变体。来自无支原体、感染突变体的细胞提取物在体外具有抗膦乙酸的DNA聚合酶活性。这有力地表明，所选突变存在于这些病毒的HCMV DNA聚合酶基因中。