Tollemeto Matteo, Welzen Pascal L W, Thamdrup Lasse H E, Li Yudong, Patiño Padial Tania, Boisen Anja, van Hest Jan
The Danish National Research Foundation and Villum Foundation's Center IDUN Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherland.
Angew Chem Int Ed Engl. 2025 Feb 3;64(6):e202419087. doi: 10.1002/anie.202419087. Epub 2024 Nov 20.
Semipermeable polymersomes, a class of polymeric vesicles that allow molecular passage across their membranes, offer significant potential for controlled drug delivery. These vesicles can be designed for inherent or selective permeability through the choice of suitable copolymers or the incorporation of protein nanopores, respectively. In this study, we explore a novel approach using oxygen-producing enzymatic reactions within biodegradable poly(ethylene glycol)-poly(caprolactone-gradient-trimethylene carbonate) (PEG-p(CL-g-TMC)) polymersomes to modulate drug release. These polymersomes were found to enhance the release of hydrophobic drugs while retaining hydrophilic drugs. The enzymatic generation of oxygen within the polymersomes increased membrane hydrophobicity, influencing drug release kinetics. The findings highlight the importance of understanding drug release kinetics in designing effective drug delivery systems, as the release rate and mechanism critically impact therapeutic efficacy and patient outcomes.
半透性聚合物囊泡是一类允许分子穿过其膜的聚合物囊泡，在可控药物递送方面具有巨大潜力。这些囊泡可以分别通过选择合适的共聚物或掺入蛋白质纳米孔来设计成具有固有渗透性或选择性渗透性。在本研究中，我们探索了一种在可生物降解的聚（乙二醇）-聚（己内酯-梯度-三亚甲基碳酸酯）（PEG-p(CL-g-TMC)）聚合物囊泡内利用产氧酶促反应来调节药物释放的新方法。发现这些聚合物囊泡能增强疏水性药物的释放，同时保留亲水性药物。聚合物囊泡内氧气的酶促生成增加了膜的疏水性，影响药物释放动力学。这些发现突出了在设计有效的药物递送系统时理解药物释放动力学的重要性，因为释放速率和机制对治疗效果和患者预后有着至关重要的影响。
