Mathesh Motilal, Sun Jiawei, van der Sandt Frans, Wilson Daniela A
Institute of Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Nanoscale. 2020 Nov 19;12(44):22495-22501. doi: 10.1039/d0nr04415f.
Self-propelled nanomotors demonstrating autonomous motion in biologically relevant fuel are currently being studied to overcome the use of external physical or chemical stimuli as precise delivery agents. In this context, the tumor microenvironment (TME) with slightly acidic pH is used for developing cargo-releasing artificial systems triggered by such conditions. However, there is still a need for fabrication of smart nanomotors that can sense the acidic pH prevalent in the TME rather than using an external fuel source for selective activation and thereafter migrating towards tumors for active drug delivery. Herein, supramolecular assembly-based nanomotors are fabricated by in-situ grown CaCO3 nanoparticles and studied for their motility behaviour in endogenously generated acidic pH by HeLa cells and further exploited as an active delivery vehicle for DOX molecules to the cells for their anticancer efficacy. The nanomotors are activated in slightly acidic pH showcasing "pH taxis" towards tumor cells without the need for any sophisticated/complicated technologies or an external fuel source for active and targeted delivery of drugs.
目前正在研究能够在生物相关燃料中自主运动的自驱动纳米马达，以克服使用外部物理或化学刺激作为精确递送剂的问题。在此背景下，具有微酸性pH值的肿瘤微环境被用于开发由这种条件触发的货物释放人工系统。然而，仍然需要制造能够感知肿瘤微环境中普遍存在的酸性pH值的智能纳米马达，而不是使用外部燃料源进行选择性激活，然后向肿瘤迁移以进行主动药物递送。在此，基于超分子组装的纳米马达由原位生长的碳酸钙纳米颗粒制备而成，并研究了它们在HeLa细胞内源性产生的酸性pH值中的运动行为，并进一步用作将阿霉素分子主动递送至细胞的载体，以发挥其抗癌功效。纳米马达在微酸性pH值下被激活，展示出对肿瘤细胞的“pH趋化性”，无需任何复杂的技术或外部燃料源即可实现药物的主动和靶向递送。
