两种同源驱动蛋白在哺乳动物活动纤毛中的不同作用。

Distinct roles of two homologous kinesins in mammalian motile cilia.

机构信息

Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University , Beijing, China.

出版信息

J Cell Biol. 2024 Nov 4;223(11). doi: 10.1083/jcb.202409214. Epub 2024 Oct 24.

DOI:10.1083/jcb.202409214

PMID:39446171

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11513245/

Abstract

How do the two kinesin-9 members Kif6 and Kif9 function in mammalian cilia? Ou and colleagues discuss new work from Fang et al. (https://doi.org/10.1083/jcb.202312060) showing that Kif6 is an active motor while Kif9 serves as a stationary regulator, both of which are essential for cilia motility.

摘要

这两个 kinesin-9 成员 Kif6 和 Kif9 在哺乳动物纤毛中是如何发挥作用的？Ou 及其同事讨论了 Fang 等人的新工作（https://doi.org/10.1083/jcb.202312060），该工作表明 Kif6 是一个活跃的马达，而 Kif9 作为一个固定的调节剂，两者对于纤毛运动都是必不可少的。