Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, 430022, China.
Curr Med Sci. 2024 Oct;44(5):883-889. doi: 10.1007/s11596-024-2935-6. Epub 2024 Oct 24.
3,3',5-Triiodo-L-thyronine (T3) is a key endocrine hormone in the human body that plays crucial roles in growth, development, metabolism, and immune function. Macrophages, the key regulatory cells within the immune system, exhibit marked "heterogeneity" and "plasticity", with their phenotype and function subject to modulation by local environmental signals. The interplay between the endocrine and immune systems is well documented. Numerous studies have shown that T3 significantly target macrophages, highlighting them as key cellular components in this interaction. Through the regulation of macrophage function and phenotype, T3 influences immune function and tissue repair in the body. This review comprehensively summarizes the regulatory actions and mechanisms of T3 on macrophages, offering valuable insights into further research of the immunoregulatory effects of T3.
三碘甲状腺原氨酸（T3）是人体中的一种关键内分泌激素，在生长、发育、代谢和免疫功能中发挥着至关重要的作用。巨噬细胞是免疫系统中的关键调节细胞，表现出明显的“异质性”和“可塑性”，其表型和功能受到局部环境信号的调节。内分泌系统和免疫系统之间的相互作用已有大量记载。许多研究表明，T3 可显著靶向巨噬细胞，凸显其在这种相互作用中的关键细胞组成部分。通过调节巨噬细胞的功能和表型，T3 影响着体内的免疫功能和组织修复。本综述全面总结了 T3 对巨噬细胞的调节作用及其机制，为进一步研究 T3 的免疫调节作用提供了有价值的见解。
