工业溶剂污染饮用水致美国海军陆战队勒琼营海军陆战队员和海军人员及平民癌症发病率：队列研究。

Cancer Incidence among Marines and Navy Personnel and Civilian Workers Exposed to Industrial Solvents in Drinking Water at US Marine Corps Base Camp Lejeune: A Cohort Study.

机构信息

Office of Community Health Hazard Assessment, Health Studies Section, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA.

Health Research and Analytics Division, Battelle Memorial Institute, Charlottesville, Virginia, USA.

出版信息

Environ Health Perspect. 2024 Oct;132(10):107008. doi: 10.1289/EHP14966. Epub 2024 Oct 24.

DOI:10.1289/EHP14966

PMID:39446420

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11500795/

Abstract

BACKGROUND

Drinking water at US Marine Corps Base Camp Lejeune, North Carolina, was contaminated with trichloroethylene and other industrial solvents from 1953 to 1985.

METHODS

A cohort cancer incidence study was conducted of Marines/Navy personnel who began service and were stationed at Camp Lejeune () or Camp Pendleton, California () between 1975 and 1985 and civilian workers employed at Camp Lejeune () or Camp Pendleton () between October 1972 and December 1985. Camp Pendleton's drinking water was not contaminated with industrial solvents. Individual-level information on primary invasive cancers and bladder cancer diagnosed between 1996 and 2017 was obtained from 54 US cancer registries. Proportional hazards regression was used to calculate adjusted hazard ratios (aHRs) comparing cancer incidence between the Camp Lejeune and Camp Pendleton cohorts, adjusted for sex, race, education, and rank (or blue-collar work), with age as the time variable. Precision of aHRs was evaluated using the 95% confidence interval (CI) ratio (CIR).

RESULTS

Cancers among Camp Lejeune Marines/Navy personnel and civilian workers totaled 12,083 and 1,563, respectively. Cancers among Camp Pendleton Marines/Navy personnel and civilian workers totaled 12,144 and 1,416, respectively. Compared with Camp Pendleton, Camp Lejeune Marines/Navy personnel had aHRs with CIRs for all myeloid cancers (; 95% CI: 1.03, 1.49), acute myeloid leukemia (; 95% CI: 1.03, 1.85), myelodysplastic and myeloproliferative syndromes (; 95% CI: 1.07, 2.62), polycythemia vera (; 95% CI: 0.94, 2.11), and cancers of the esophagus (; 95% CI: 1.03, 1.56), larynx (; 95% CI: 0.98, 1.50), soft tissue (; 95% CI: 0.92, 1.59), and thyroid (; 95% CI: 1.03, 1.45). Lymphoma subtypes mantle cell and marginal zone B-cell and lung cancer subtypes adenocarcinoma and non-small cell lung cancer also had aHRs with CIRs . Compared with Camp Pendleton, Camp Lejeune civilian workers had aHRs with CIRs for all myeloid cancers (; 95% CI: 0.83, 2.36), squamous cell lung cancer (; 95% CI: 1.10, 2.41), and female breast (; 95% CI: 0.97, 1.52) and ductal cancer (; 95% CI: 1.02, 1.71).

CONCLUSION

Increased risks of several cancers were observed among Marines/Navy personnel and civilian workers exposed to contaminated drinking water at Camp Lejeune compared with Camp Pendleton. https://doi.org/10.1289/EHP14966.

摘要

背景

1953 年至 1985 年，美国北卡罗来纳州勒琼营的饮用水受到三氯乙烯和其他工业溶剂的污染。

方法

对 1975 年至 1985 年间在勒琼营或加利福尼亚州彭德尔顿营服役和驻扎的海军陆战队员/海军人员以及 1972 年 10 月至 1985 年 12 月期间在勒琼营或彭德尔顿营工作的文职人员进行了队列癌症发病率研究。彭德尔顿营的饮用水没有受到工业溶剂的污染。通过 54 个美国癌症登记处，获得了 1996 年至 2017 年期间诊断的原发性侵袭性癌症和膀胱癌的个体水平信息。使用比例风险回归比较了勒琼营和彭德尔顿营队列的癌症发病率，调整了性别、种族、教育程度和等级（或蓝领工作），年龄为时间变量。使用 95%置信区间（CI）比值（CIR）评估了危险比（aHR）的精度。

结果

在勒琼营的海军陆战队员/海军人员和文职人员中，癌症总计为 12083 例和 1563 例。在彭德尔顿营的海军陆战队员/海军人员和文职人员中，癌症分别为 12144 例和 1416 例。与彭德尔顿营相比，勒琼营的海军陆战队员/海军人员的所有髓系癌症（aHR 比值为 1.03，95%CI 为 1.03 至 1.49）、急性髓系白血病（aHR 比值为 1.03，95%CI 为 1.03 至 1.85）、骨髓增生异常和骨髓增生性综合征（aHR 比值为 1.07，95%CI 为 1.07 至 2.62）、真性红细胞增多症（aHR 比值为 0.94，95%CI 为 0.94 至 2.11）、食管（aHR 比值为 1.03，95%CI 为 1.03 至 1.56）、喉（aHR 比值为 0.98，95%CI 为 0.98 至 1.50）、软组织（aHR 比值为 0.92，95%CI 为 0.92 至 1.59）和甲状腺（aHR 比值为 1.03，95%CI 为 1.03 至 1.45）也存在 aHR。套细胞淋巴瘤和边缘区 B 细胞淋巴瘤亚型以及腺癌和非小细胞肺癌也存在 aHR，CIR 比值为。与彭德尔顿营相比，勒琼营的文职人员的所有髓系癌症（aHR 比值为 0.83，95%CI 为 0.83 至 2.36）、鳞状细胞肺癌（aHR 比值为 1.10，95%CI 为 1.10 至 2.41）和女性乳腺癌（aHR 比值为 0.97，95%CI 为 0.97 至 1.52）和导管癌（aHR 比值为 1.02，95%CI 为 1.02 至 1.71）也存在 aHR。