基于网络的干预（Deprexis）对降低退伍军人抑郁和恢复功能的评估：一项随机对照试验的方案。
The Evaluation of a Web-Based Intervention (Deprexis) to Decrease Depression and Restore Functioning in Veterans: Protocol for a Randomized Controlled Trial.
机构信息
Veterans Integrated Service Network 17 Center of Excellence for Research on Returning War Veterans, Central Texas Veterans Affairs Healthcare System, Waco, TX, United States.
Department of Psychology and Institute for Mental Health Research, University of Texas at Austin, Austin, TX, United States.
出版信息
JMIR Res Protoc. 2024 Oct 24;13:e59119. doi: 10.2196/59119.
BACKGROUND
Depressive symptoms are common in veterans, and the presence of these symptoms increases disability as well as suicidal thoughts and behaviors. However, there is evidence that these symptoms often go untreated. Intervening before symptoms become severe and entrenched is related to better long-term outcomes, including improved functioning and less disease chronicity. Computer-delivered interventions may be especially appropriate for those veterans with mild to moderate depressive symptoms, because these interventions can require fewer resources and have lower barriers to access and thus have potential for wider reach. Despite this potential, there is a dearth of research examining computerized interventions for depressive symptoms in veteran samples.
OBJECTIVE
The aim of this study is to evaluate the efficacy of Deprexis (GAIA AG), a computerized intervention for depressive symptoms and related functional impairment.
METHODS
Veterans will be recruited through the US Department of Veterans Affairs electronic medical record and through primary care and specialty clinics. First, qualitative interviews will be completed with a small subset of veterans (n=16-20) to assess the acceptability of treatment procedures. Next, veterans (n=132) with mild to moderate depressive symptoms will be randomly assigned to the fully automated Deprexis intervention or a treatment-as-usual control group. The primary outcomes will be self-reported depressive symptoms and various dimensions of psychosocial functioning.
RESULTS
This project was funded in May 2024, and data collection will be conducted between October 2024 and April 2029. Overall, 4 participants have been recruited as of the submission of the manuscript, and data analysis is expected in June 2029, with initial results expected in November 2029.
CONCLUSIONS
This study will provide initial evidence for the efficacy of self-guided, computerized interventions for depressive symptoms and functional impairment in veterans. If effective, these types of interventions could improve veteran access to low-resource psychosocial treatments.
TRIAL REGISTRATION
ClinicalTrials.gov NCT06217198; https://www.clinicaltrials.gov/study/NCT06217198.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/59119.
背景
抑郁症状在退伍军人中很常见，这些症状的存在不仅会增加残疾的可能性，还会增加自杀的想法和行为。然而，有证据表明，这些症状往往得不到治疗。在症状变得严重和根深蒂固之前进行干预，与更好的长期结果相关，包括改善功能和减少疾病的慢性化。计算机提供的干预措施对于那些有轻度至中度抑郁症状的退伍军人可能特别合适，因为这些干预措施可能需要更少的资源，并且访问的障碍更小，因此可能具有更广泛的应用潜力。尽管有这种潜力，但针对退伍军人样本中的抑郁症状的计算机化干预措施的研究却很少。
目的
本研究旨在评估 Deprexis（GAIA AG），一种用于抑郁症状和相关功能障碍的计算机化干预措施的疗效。
方法
退伍军人将通过美国退伍军人事务部的电子病历以及初级保健和专科诊所招募。首先，将对一小部分退伍军人（n=16-20）进行定性访谈，以评估治疗程序的可接受性。接下来，将 132 名有轻度至中度抑郁症状的退伍军人随机分配到完全自动化的 Deprexis 干预组或常规治疗对照组。主要结果将是自我报告的抑郁症状和各种心理社会功能维度。
结果
该项目于 2024 年 5 月获得资助，数据收集将于 2024 年 10 月至 2029 年 4 月进行。截至提交稿件时，已有 4 名参与者被招募，数据分析预计于 2029 年 6 月进行，初步结果预计于 2029 年 11 月公布。
结论
本研究将为退伍军人的自我指导、计算机化干预措施对抑郁症状和功能障碍的疗效提供初步证据。如果有效，这些类型的干预措施可以改善退伍军人获得低资源心理社会治疗的机会。
试验注册
ClinicalTrials.gov NCT06217198；https://www.clinicaltrials.gov/study/NCT06217198。
国际注册报告标识符（IRRID）：PRR1-10.2196/59119。
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