Eisemann J H, Tyrrell H F, Hammond A C, Reynolds P J, Bauman D E, Haaland G L, McMurtry J P, Varga G A
J Nutr. 1986 Jan;116(1):157-63. doi: 10.1093/jn/116.1.157.
The objective was to determine the effect of daily s.c. injection of bovine growth hormone (bGH) on nitrogen and energy balance in six Hereford heifers. In addition, effects on urinary excretion of 3-methylhistidine and hydroxyproline and on serum mineral concentrations were monitored. A single reversal design was used with two 14-d injection periods of placebo or bGH (29.2 IU/d). Measurements were made on d 8-14 of each period. Injection of bGH did not alter apparent digestibility of dry matter, energy or nitrogen, nor urinary excretion of 3-methylhistidine or hydroxyproline. Serum concentrations of calcium, phosphorus and magnesium were normal with bGH treatment. Nitrogen retention was higher and urinary nitrogen excretion was lower when the heifers were injected with bGH than with the placebo demonstrating an effect of bGH on postabsorptive metabolism of nitrogen. Total energy balance was not altered by treatment. Energy retained as protein was higher after bGH treatment than after the placebo, implying decreased energy retained as fat and demonstrating a role for GH in altering energy partition in growing animals. Total heat production was not altered by treatment indicating no change in the gross efficiency of metabolizable energy use with bGH treatment.
目的是确定每日皮下注射牛生长激素（bGH）对6头赫里福德小母牛氮和能量平衡的影响。此外，还监测了对3-甲基组氨酸和羟脯氨酸尿排泄以及血清矿物质浓度的影响。采用单逆转设计，进行两个为期14天的注射期，分别注射安慰剂或bGH（29.2 IU/天）。在每个时期的第8 - 14天进行测量。注射bGH并未改变干物质、能量或氮的表观消化率，也未改变3-甲基组氨酸或羟脯氨酸的尿排泄。bGH处理后血清钙、磷和镁浓度正常。与注射安慰剂相比，注射bGH的小母牛氮潴留更高，尿氮排泄更低，表明bGH对氮的吸收后代谢有影响。处理未改变总能量平衡。bGH处理后作为蛋白质保留的能量高于安慰剂处理后，这意味着作为脂肪保留的能量减少，表明生长激素在改变生长动物的能量分配中起作用。处理未改变总产热，表明bGH处理后可代谢能量使用的总效率没有变化。
