Knight M E, Roberts R J
J Pediatr. 1986 Jan;108(1):145-50. doi: 10.1016/s0022-3476(86)80794-6.
Newborn rabbits were given a single intravenous dose (100 mg/kg) of either alpha-tocopherol or alpha-tocopheryl acetate to compare disposition characteristics of these two forms of vitamin E. The resulting tissue concentrations of alpha-tocopherol and alpha-tocopheryl acetate differed significantly. Tissue concentrations of either form of vitamin E were much higher than those provided by normal nutrition, and remained unchanged (except in the liver) for 6 days after dose. alpha-Tocopheryl acetate was not completely converted to alpha-tocopherol, and only 50% of the dose was recovered 3 days after administration. The entire dose of alpha-tocopherol was recovered intact 3 days after administration. The persistence of very high tissue vitamin E concentrations after a single intravenous dosing, the disappearance from the body of half of the administered dose of alpha-tocopheryl acetate, and the lack of complete conversion of alpha-tocopheryl acetate to alpha-tocopherol when given intravenously have profound implications regarding the current clinical practice of giving repeated pharmacologic doses of vitamin E to newborn infants.
给新生兔静脉注射单剂量（100毫克/千克）的α-生育酚或α-生育酚醋酸酯，以比较这两种形式的维生素E的处置特征。结果显示，α-生育酚和α-生育酚醋酸酯的组织浓度存在显著差异。两种形式的维生素E的组织浓度均远高于正常营养所提供的浓度，给药后6天内保持不变（肝脏除外）。α-生育酚醋酸酯并未完全转化为α-生育酚，给药3天后仅回收了50%的剂量。静脉注射α-生育酚后3天，整个剂量均完整回收。单次静脉给药后组织中维生素E浓度持续极高，α-生育酚醋酸酯给药剂量的一半从体内消失，以及静脉注射时α-生育酚醋酸酯未完全转化为α-生育酚，这些情况对目前给新生儿反复给予药理剂量维生素E的临床实践具有深远影响。
