Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Department of Gynecology and Obstetrics Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
PLoS One. 2024 Oct 24;19(10):e0310238. doi: 10.1371/journal.pone.0310238. eCollection 2024.
To determine the safety and effectiveness of ultrasound-guided paracervical nerve blocks for the painless treatment of patients with cervical cancer post-implantation.
Single-center randomized controlled trial.
Fourth Hospital of Hebei Medical University (July 2023 to October 2023).
ChiCTR2300071580 [https://clin.larvol.com/trial-detail/ChiCTR2300071580].
Eighty patients with cervical cancer underwent post-implantation treatment.
Patients receiving and not receiving paracervical nerve blocks (Groups T and C, respectively) were randomly allocated.
Primary measures included visual analog scale (VAS) scores and patient body movement scores at various stages, including vaginal speculum placement (T1), applicator/needle insertion (T2), treatment administration following connection of the treatment tube (T3), needle withdrawal and hemostasis (T4), and willingness to receive further treatment. The secondary observation indices in this study included the operation time, incidence of hypoxemia, occurrence of nausea and vomiting, adverse events related to the circulatory system, patient satisfaction score, operator satisfaction score, and operation duration required by patients with an Alderte score of ≥ 9.
Forty patients each were randomly allocated into Groups T and C. The VAS scores did not differ significantly between the two groups at T1. However, at T3 and T4, the VAS scores of Group T was significantly lower than that of Group C. No significant difference was observed in the body movement scores between the two groups at T1 and T3. However, the body movement score of Group T was significantly lower than that of Group C (P < 0.001) at T2 and T4. Group T showed higher postoperative satisfaction and willingness to receive further treatment compared to that of Group C.
Ultrasound-guided paracervical nerve block effectively reduced the pain scores in patients with cervical cancer undergoing post-implantation treatment and enhanced their inclination to undergo further treatment.
确定超声引导下子宫旁神经阻滞用于无痛治疗宫颈癌患者植入后的安全性和有效性。
单中心随机对照试验。
河北医科大学第四医院（2023 年 7 月至 2023 年 10 月）。
ChiCTR2300071580 [https://clin.larvol.com/trial-detail/ChiCTR2300071580]。
80 例宫颈癌患者接受植入后治疗。
接受和不接受子宫旁神经阻滞的患者（分别为 T 组和 C 组）随机分配。
主要措施包括视觉模拟评分（VAS）和患者在不同阶段的身体运动评分，包括阴道窥器放置（T1）、施源器/针插入（T2）、连接治疗管后治疗给药（T3）、针拔出和止血（T4），以及是否愿意接受进一步治疗。本研究的次要观察指标包括手术时间、低氧血症发生率、恶心呕吐发生情况、与循环系统相关的不良事件、患者满意度评分、操作人员满意度评分以及 Alderte 评分≥9 分的患者所需的手术时间。
每组 40 例患者随机分配至 T 组和 C 组。两组在 T1 时 VAS 评分无显著差异。然而，在 T3 和 T4 时，T 组的 VAS 评分明显低于 C 组。两组在 T1 和 T3 时身体运动评分无显著差异。然而，T2 和 T4 时 T 组的身体运动评分明显低于 C 组（P<0.001）。T 组的术后满意度和进一步治疗意愿明显高于 C 组。
超声引导下子宫旁神经阻滞可有效降低宫颈癌患者植入后治疗的疼痛评分，增强其进一步治疗的倾向。
