State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 510060, Guangzhou, China.
Química y Farmacia, Facultad de Ciencias de La Salud, Universidad Arturo Prat, 1100000, Iquique, Chile; Instituto de Química Medicinal, Universidad Arturo Prat, 1100000, Iquique, Chile; Research Group in Metabolism and Nutrition, Louvain Drug Research Institute, Université Catholique de Louvain, 1200, Brussels, Belgium.
Redox Biol. 2024 Nov;77:103404. doi: 10.1016/j.redox.2024.103404. Epub 2024 Oct 19.
Healthy cells have developed a sophisticated network of antioxidant molecules to prevent the toxic accumulation of reactive oxygen species (ROS) generated by diverse environmental stresses. On the opposite, cancer cells often exhibit high levels of ROS and an altered levels of antioxidant molecules compared to normal cells. Among them, the antioxidant enzyme catalase plays an essential role in cell defense against oxidative stress through the dismutation of hydrogen peroxide into water and molecular oxygen, and its expression is often decreased in cancer cells. The elevation of ROS in cancer cells provides them proliferative advantages, and leads to metabolic reprogramming, immune escape and metastasis. In this context, catalase is of critical importance to control these cellular processes in cancer through various mechanisms. In this review, we will discuss the major progresses and challenges in understanding the role of catalase in cancer for this last decade. This review also aims to provide important updates regarding the regulation of catalase expression, subcellular localization and discuss about the potential role of microbial catalases in tumor environment. Finally, we will describe the different catalase-based therapies and address the advantages, disadvantages, and limitations associated with modulating catalase therapeutically in cancer treatment.
健康细胞已经发展出一套复杂的抗氧化分子网络，以防止由各种环境应激产生的活性氧（ROS）的毒性积累。相反，与正常细胞相比，癌细胞通常表现出高水平的 ROS 和改变的抗氧化分子水平。其中，抗氧化酶过氧化氢酶通过将过氧化氢歧化为水和分子氧，在细胞防御氧化应激中发挥重要作用，其表达在癌细胞中常常降低。ROS 在癌细胞中的升高为其提供了增殖优势，并导致代谢重编程、免疫逃逸和转移。在这种情况下，过氧化氢酶通过各种机制对控制这些细胞过程至关重要。在这篇综述中，我们将讨论过去十年中理解过氧化氢酶在癌症中的作用的主要进展和挑战。这篇综述还旨在提供关于过氧化氢酶表达、亚细胞定位的重要更新，并讨论微生物过氧化氢酶在肿瘤环境中的潜在作用。最后，我们将描述基于过氧化氢酶的不同治疗方法，并讨论在癌症治疗中调节过氧化氢酶治疗的相关优势、劣势和限制。
