Department of Operating Room, Student Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Anesthesiology, Operating Room, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran; Complementary and Traditional Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Int J Orthop Trauma Nurs. 2024 Nov;55:101140. doi: 10.1016/j.ijotn.2024.101140. Epub 2024 Oct 18.
Complex regional pain syndrome type I (CRPS-I) is a specific type of persistent pain which is often caused by fracture and surgery. There is no effective curative therapy available. However some studies have indicated that Vitamin C (VC) can reduce the incidence of CRPS-I. This study's objective is to investigate the effectiveness VC in preventing and treating CRPS-I.
An Systematic review and Meta-analysis was done.
Primary research studies from PubMed, Scopus, Web of Science, ProQuest, Embase database, and Cochran Library, and Google Scholar were reviewed. This search was conducted until March 27, 2024. This study was conducted without any language, place, and time restrictions. Study results were meta-analyzed with using effect sizes. To evaluate heterogeneity, we employed the Cochrane Q test and the I2 index.
In our systematic review, 3947 articles were initially identified, with 3939 excluded for not meeting inclusion criteria, resulting in 8 studies being critically evaluated using Cochran's risk of bias checklist. The meta-analysis revealed that VC supplementation have effect on reducing CRPS-I post-limb surgery but this result shows that the pooled effect size is not statistically significant. The heterogeneity of the studies was low (I = 26.28%, p = 0.22). Publication bias was detected, indicating asymmetry in the funnel plot.
The results of our study showed the positive effect of VC supplementation in reducing the prevalence of CRPS-I after limb surgery.
复杂性区域疼痛综合征 I 型（CRPS-I）是一种特定类型的持续性疼痛，通常由骨折和手术引起。目前尚无有效的治疗方法。然而，一些研究表明维生素 C（VC）可以降低 CRPS-I 的发生率。本研究旨在探讨 VC 预防和治疗 CRPS-I 的效果。
系统评价和荟萃分析。
从 PubMed、Scopus、Web of Science、ProQuest、Embase 数据库和 Cochrane 图书馆以及 Google Scholar 检索原始研究。该检索截至 2024 年 3 月 27 日进行。本研究没有语言、地点和时间限制。使用效应大小对研究结果进行荟萃分析。为了评估异质性，我们采用了 Cochrane Q 检验和 I² 指数。
在我们的系统评价中，最初确定了 3947 篇文章，其中 3939 篇因不符合纳入标准而被排除，使用 Cochrane 偏倚风险检查表对 8 项研究进行了严格评估。荟萃分析显示，VC 补充剂对减少肢体手术后的 CRPS-I 有影响，但该结果表明，汇总效应大小无统计学意义。研究的异质性较低（I²=26.28%，p=0.22）。存在发表偏倚，表明漏斗图不对称。
我们的研究结果表明，VC 补充剂在减少肢体手术后 CRPS-I 的发生率方面具有积极作用。
