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Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film.

作者信息

Nador Ellena, Mausser Emilie, Marathe Jai G, Politch Joseph A, Thurman Andrea R, Whaley Kevin J, Anderson Deborah J

机构信息

Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.

Dare Bioscience, San Diego, California.

出版信息

Fertil Steril. 2025 Mar;123(3):534-536. doi: 10.1016/j.fertnstert.2024.10.026. Epub 2024 Oct 22.

DOI:10.1016/j.fertnstert.2024.10.026
PMID:39447830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12269741/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb3/12269741/bf2ab41c8b66/nihms-2096119-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb3/12269741/bf95b0ead642/nihms-2096119-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb3/12269741/bf2ab41c8b66/nihms-2096119-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb3/12269741/bf95b0ead642/nihms-2096119-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdb3/12269741/bf2ab41c8b66/nihms-2096119-f0002.jpg

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Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film.宫颈内抗体依赖的补体介导的精子细胞毒性是ZB-06阴道膜的主要避孕机制。
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本文引用的文献

1
LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity.人避孕抗体(HCA)的 LALAPG 变异体降低了 Fc 介导的效应功能,同时保持了精子凝集活性。
PLoS One. 2023 Mar 30;18(3):e0282147. doi: 10.1371/journal.pone.0282147. eCollection 2023.
2
ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.ZB-06,一种含有工程化的人用避孕抗体(HC4-N)的阴道膜,在一项 1 期事后避孕测试和安全性研究中表现出安全性和有效性。
Am J Obstet Gynecol. 2023 Jun;228(6):716.e1-716.e12. doi: 10.1016/j.ajog.2023.02.024. Epub 2023 Mar 2.
3
Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women.
生产和鉴定一种人源抗精子单克隆抗体针对 CD52g 用于女性的局部避孕。
EBioMedicine. 2021 Jul;69:103478. doi: 10.1016/j.ebiom.2021.103478. Epub 2021 Jul 10.
4
Engineering monoclonal antibody-based contraception and multipurpose prevention technologies†.基于工程单克隆抗体的避孕和多用途预防技术。
Biol Reprod. 2020 Aug 4;103(2):275-285. doi: 10.1093/biolre/ioaa096.
5
Immunology of infertility.不孕症的免疫学
Clin Obstet Gynaecol. 1981 Dec;8(3):611-39.
6
The presence of complement in human cervical mucus and its possible relevance to infertility in women with complement-dependent sperm-immobilizing antibodies.
Fertil Steril. 1979 Jul;32(1):61-6. doi: 10.1016/s0015-0282(16)44117-8.