Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film.
作者信息
Nador Ellena, Mausser Emilie, Marathe Jai G, Politch Joseph A, Thurman Andrea R, Whaley Kevin J, Anderson Deborah J
机构信息
Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Dare Bioscience, San Diego, California.
出版信息
Fertil Steril. 2025 Mar;123(3):534-536. doi: 10.1016/j.fertnstert.2024.10.026. Epub 2024 Oct 22.
Abstract
摘要
相似文献
1
Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film.宫颈内抗体依赖的补体介导的精子细胞毒性是ZB-06阴道膜的主要避孕机制。
Fertil Steril. 2025 Mar;123(3):534-536. doi: 10.1016/j.fertnstert.2024.10.026. Epub 2024 Oct 22.
2
ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.ZB-06，一种含有工程化的人用避孕抗体（HC4-N）的阴道膜，在一项 1 期事后避孕测试和安全性研究中表现出安全性和有效性。
Am J Obstet Gynecol. 2023 Jun;228(6):716.e1-716.e12. doi: 10.1016/j.ajog.2023.02.024. Epub 2023 Mar 2.
3
Influenza-specific antibody-mediated and complement-dependent cellular cytotoxicity-inducing antibodies in vaccinated and infected pigs.接种疫苗和感染后的猪体内的流感特异性抗体介导的及补体依赖的细胞毒性诱导抗体
Front Immunol. 2025 Jun 30;16:1600761. doi: 10.3389/fimmu.2025.1600761. eCollection 2025.
5
Modern combined oral contraceptives for pain associated with endometriosis.用于治疗子宫内膜异位症相关疼痛的现代复方口服避孕药。
Cochrane Database Syst Rev. 2000(2):CD001019. doi: 10.1002/14651858.CD001019.
6
Skin patch and vaginal ring versus combined oral contraceptives for contraception.皮肤贴片和阴道环与复方口服避孕药用于避孕的比较。
Cochrane Database Syst Rev. 2003(1):CD003552. doi: 10.1002/14651858.CD003552.
7
Skin patch and vaginal ring versus combined oral contraceptives for contraception.皮肤贴片和阴道环与复方口服避孕药用于避孕的比较。
Cochrane Database Syst Rev. 2013 Apr 30;2013(4):CD003552. doi: 10.1002/14651858.CD003552.pub4.
8
Tissue-based Immunohistochemical Biomarker Accuracy in the Diagnosis of Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review of the Literature and Meta-Analysis.基于组织的免疫组化生物标志物在子宫颈恶性腺性病变诊断中的准确性：文献系统评价与Meta分析
Int J Gynecol Pathol. 2017 Jul;36(4):310-322. doi: 10.1097/PGP.0000000000000345.
10
Safety of the progesterone-releasing vaginal ring (PVR) among lactating women: A systematic review.哺乳期妇女使用含孕酮阴道环（PVR）的安全性：一项系统评价。
Contraception. 2016 Sep;94(3):253-61. doi: 10.1016/j.contraception.2015.04.001. Epub 2015 Apr 11.
本文引用的文献
1
LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity.人避孕抗体（HCA）的 LALAPG 变异体降低了 Fc 介导的效应功能，同时保持了精子凝集活性。
PLoS One. 2023 Mar 30;18(3):e0282147. doi: 10.1371/journal.pone.0282147. eCollection 2023.
2
ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.ZB-06，一种含有工程化的人用避孕抗体（HC4-N）的阴道膜，在一项 1 期事后避孕测试和安全性研究中表现出安全性和有效性。
Am J Obstet Gynecol. 2023 Jun;228(6):716.e1-716.e12. doi: 10.1016/j.ajog.2023.02.024. Epub 2023 Mar 2.
3
Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women.生产和鉴定一种人源抗精子单克隆抗体针对 CD52g 用于女性的局部避孕。
EBioMedicine. 2021 Jul;69:103478. doi: 10.1016/j.ebiom.2021.103478. Epub 2021 Jul 10.
4
Engineering monoclonal antibody-based contraception and multipurpose prevention technologies†.基于工程单克隆抗体的避孕和多用途预防技术。
Biol Reprod. 2020 Aug 4;103(2):275-285. doi: 10.1093/biolre/ioaa096.
5
Immunology of infertility.不孕症的免疫学
Clin Obstet Gynaecol. 1981 Dec;8(3):611-39.
6
The presence of complement in human cervical mucus and its possible relevance to infertility in women with complement-dependent sperm-immobilizing antibodies.
Fertil Steril. 1979 Jul;32(1):61-6. doi: 10.1016/s0015-0282(16)44117-8.
Zotero 插件