Adams N R, Tang B Y
J Reprod Fertil. 1986 Jan;76(1):147-52. doi: 10.1530/jrf.0.0760147.
The amount of cervical mucus recovered from control ovariectomized ewes increased with increasing doses of oestradiol benzoate (OB), while the maximum Spinnbarkeit of mucus occurred at an intermediate dose of OB. Neither the amount nor the Spinnbarkeit of mucus varied with the dose of OB in ewes with permanent infertility caused by grazing oestrogenic pasture (clover-affected ewes). Furthermore, the increase in Spinnbarkeit of cervical mucus seen in normal ewes treated over a 3-day period with OB or with implants containing oestradiol did not occur in affected ewes. In control ewes treated repeatedly with OB, production of mucus declined within 5 days, but no change in secretion was detectable in clover-affected ewes. Therefore, neither the amount nor the duration of oestrogenic stimulation affected the cervical mucus in ewes with clover disease. Affected ewes produced more mucus than did controls in the absence of oestrogenic stimulation. It is concluded that the relatively normal volume of mucus in affected ewes treated with OB results largely from autonomous production. The Spinnbarkeit does not increase in these ewes because the ability of the cervix to respond to oestrogen is impaired.
从切除卵巢的对照母羊收集到的宫颈黏液量随着苯甲酸雌二醇（OB）剂量的增加而增加，而黏液的最大拉丝度出现在OB的中间剂量。对于因采食雌激素性牧草（三叶草影响的母羊）导致永久性不孕的母羊，黏液的量和拉丝度均不随OB剂量变化。此外，正常母羊用OB或含雌二醇的植入物处理3天，宫颈黏液的拉丝度增加，但在受影响的母羊中未出现这种情况。在反复用OB处理的对照母羊中，黏液分泌在5天内减少，但在三叶草影响的母羊中未检测到分泌变化。因此，雌激素刺激的量和持续时间均不影响患有三叶草病的母羊的宫颈黏液。在无雌激素刺激的情况下，受影响的母羊比对照母羊产生更多的黏液。得出的结论是，用OB处理的受影响母羊中黏液量相对正常主要是由于自主分泌。这些母羊的拉丝度不增加是因为子宫颈对雌激素的反应能力受损。
