双相障碍患者的异常功能侧化和合作与神经递质和细胞特征有关。
Abnormal functional lateralization and cooperation in bipolar disorder are associated with neurotransmitter and cellular profiles.
机构信息
School of Mental Health and Psychological Sciences, Anhui Medical University, 81 Meishan Rd, Hefei 230032, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China.
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China; Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China.
出版信息
J Affect Disord. 2025 Jan 15;369:970-977. doi: 10.1016/j.jad.2024.10.108. Epub 2024 Oct 22.
BACKGROUND
Hemispheric lateralization and cooperation are essential for efficient brain function, and aberrations in both have been found in psychiatric disorders such as schizophrenia. This study investigated alterations in hemispheric lateralization and cooperation among patients with bipolar disorder (BD) and associations with neurotransmitter and cell-type density distributions to identify potential molecular and cellular pathomechanisms.
METHODS
Sixty-seven BD patients and 127 healthy controls (HCs) were examined by resting-state functional MRI (rs-fMRI). Whole-brain maps of the autonomy index (AI) and connectivity between functionally homotopic voxels (CFH) were constructed to reveal BD-specific changes in brain functional lateralization and interhemispheric cooperation, respectively. Spatial associations of regional AI and CFH abnormalities with neurotransmitter and cell-type density distributions were examined by correlation analyses.
RESULTS
Bipolar disorder patients exhibited higher AI values in left superior parietal gyrus, cerebellar right Crus I, and cerebellar right Crus II, and these regional abnormalities were associated with the relative densities (proportions) of oligodendrocyte precursor cells and microglia. Patients also exhibited lower CFH values in right inferior parietal gyrus, bilateral middle occipital gyrus, left postcentral gyrus, and bilateral cerebellar crus II, and these regional abnormalities were associated with the densities of serotonin 1A and dopamine D2 receptors, oligodendrocyte precursor cells, astrocytes, and neurons.
CONCLUSIONS
These findings indicate that abnormal functional lateralization and cooperation in BD with potential molecular and cellular basis.
背景
大脑半球的侧化和协同对于高效的大脑功能至关重要，精神分裂症等精神障碍患者中发现了这两个方面的异常。本研究通过静息态功能磁共振成像(rs-fMRI)研究了双相情感障碍(BD)患者大脑半球侧化和协同作用的改变，并与神经递质和细胞类型密度分布相关联，以确定潜在的分子和细胞病理机制。
方法
对 67 名 BD 患者和 127 名健康对照者(HCs)进行了静息态功能磁共振成像(rs-fMRI)检查。构建了自主指数(AI)和功能同态体素之间连接性(CFH)的全脑图，分别揭示了 BD 患者大脑功能侧化和半球间协同作用的特异性变化。通过相关分析研究了区域 AI 和 CFH 异常与神经递质和细胞类型密度分布的空间关联。
结果
BD 患者左顶叶上回、小脑右侧 Crus I 和小脑右侧 Crus II 的 AI 值较高，这些区域的异常与少突胶质细胞前体细胞和小胶质细胞的相对密度(比例)有关。患者右侧顶下小叶、双侧中枕叶、左侧后中央回和双侧小脑 Crus II 的 CFH 值较低，这些区域的异常与 5-羟色胺 1A 和多巴胺 D2 受体、少突胶质细胞前体细胞、星形胶质细胞和神经元的密度有关。
结论
这些发现表明，BD 患者存在异常的功能侧化和协同作用，可能有其分子和细胞基础。
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